159216-65-6

Basic information

• Product Name: cyclohexanone-4-methoxymethylether
• Synonyms: cyclohexanone-4-methoxymethylether
• CAS NO: 159216-65-6
• Molecular Weight: 158.197
• Mol File: 159216-65-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: cyclohexanone-4-methoxymethylether(CAS DataBase Reference)
• NIST Chemistry Reference: cyclohexanone-4-methoxymethylether(159216-65-6)
• EPA Substance Registry System: cyclohexanone-4-methoxymethylether(159216-65-6)

Safety Data

• Hazardous Substances Data: 159216-65-6(Hazardous Substances Data)

Upstream product

• 556-48-9 1,4-Cyclohexanediol 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 22428-87-1 4,4-ethylenedioxycyclohexan-1-ol 
• 13482-22-9 4-hydroxycyclohexanone 
• 107-30-2 chloromethyl methyl ether 
• 109-87-5 Dimethoxymethane 

Downstream Products

• 1638643-31-8 (E)-2-cinnamyl-4-(methoxymethoxy)cyclohexanone 
• 1345976-44-4 2-allyl-4-(methoxymethoxy)cyclohexanone 

Relevant articles and documents

FeCl3·6H2O/acetaldehyde, a versatile system for the deprotection of ketals and acetals via a transacetalization process

Mild and efficient catalytic deprotection of ketals/acetals mediated by FeCl3·6H2O/acetaldehyde has been described in this paper. The versatility and high chemoselectivity of the iron(iii)/aldehyde system are demonstrated by a large scope of examples. Deprotected ketones/aldehydes are nearly quantitatively isolated after filtration over a pad of silica gel followed by evaporation of volatile by-products.

Enantioselective deprotonation of protected 4-hydroxycyclohexanones

A series of derivatives of 4-hydroxycyclohexanone (1a-g) with the hydroxy group protected as a silyl ether (1a,b), ether (1d,g), an acetal (1c), or an ester (1e,f) were deprotonated with chiral, optically pure, lithium amides 3-9. The resulting non-racemic enolates were trapped as enol acetates. The enantioselectivity of deprotonation was up to 74percent ee.