159216-80-5

Basic information

• Product Name: N-benzyl-N-methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropyl-amine
• Synonyms: N-benzyl-N-methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropyl-amine
• CAS NO: 159216-80-5
• Molecular Weight: 399.456
• Mol File: 159216-80-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: N-benzyl-N-methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropyl-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-N-methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropyl-amine(159216-80-5)
• EPA Substance Registry System: N-benzyl-N-methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropyl-amine(159216-80-5)

Safety Data

• Hazardous Substances Data: 159216-80-5(Hazardous Substances Data)

Upstream product

• 54910-89-3 FLUOXETINE 
• 100-51-6 benzyl alcohol 
• 100-39-0 benzyl bromide 
• 56296-78-7 Adofen 
• 74681-55-3 3-(N-benzyl-N-methylamino)-1-phenyl-propan-1-ol 
• 103-67-3 benzyl-methyl-amine 
• 98-86-2 acetophenone 
• 21970-65-0 3-(benzyl-methyl-amino)-1-phenylpropan-1-one 
• 98-56-6 4-chlorobenzotrifluoride 

Downstream Products

• 159216-81-6 Methyl N-methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropyl-amine-N-carboxylate 
• 159216-83-8 p-nitrophenyl N-methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine-N-carboxylate 
• 848072-60-6 methyl-oxiranylmethyl-[3-phenyl-3-[4-(trifluoromethyl)-phenoxy]-propyl]amine 
• 54910-89-3 FLUOXETINE 

Relevant articles and documents

Photocatalytic Water-Splitting Coupled with Alkanol Oxidation for Selective N-alkylation Reactions over Carbon Nitride

Photocatalytic water splitting technology (PWST) enables the direct use of water as appealing “liquid hydrogen source” for transfer hydrogenation reactions. Currently, the development of PWST-based transfer hydrogenations is still in an embryonic stage. Previous reports generally centered on the rational utilization of the in situ generated H-source (electrons) for hydrogenations, in which photogenerated holes were quenched by sacrificial reagents. Herein, the fully-utilization of the liquid H-source and holes during water splitting is presented for photo-reductive N-alkylation of nitro-aromatic compounds. In this integrate system, H-species in situ generated from water splitting were designed for nitroarenes reduction to produce amines, while alkanols were oxidized by holes for cascade alkylating of anilines as well as the generated secondary amines. More than 50 examples achieved with a broad range scope validate the universal applicability of this mild and sustainable coupling approach. The synthetic utility of this protocol was further demonstrated by the synthesis of existing pharmaceuticals via selective N-alkylation of amines. This strategy based on the sustainable water splitting technology highlights a significant and promising route for selective synthesis of valuable N-alkylated fine chemicals and pharmaceuticals from nitroarenes and amines with water and alkanols.

Synthesis, anorexigenic activity and QSAR of substituted aryloxypropanolamines

Substituted aryloxypropanolamines (6-20) were synthesized and evaluated for their anorexigenic activity. Among them 4-cyanoaryloxy (7), 2-methylaryloxy (9), 2-methoxyl aryloxy (10), 4-acetamidoaryloxy (15), 4-bromoaryloxy (16) and 4-ethylaminoaryloxy (20) exhibited potent anorexigenic activity. According to QSAR studies, the electronic parameter 'σ' plays an important role in describing the variance in activity. Birkhaeuser Boston 2004.

N-substituted derivatives of N-methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine and the procedure for their preparation

The invention provides the preparation procedure for N-substituted derivatives of N-methyl-3-(p-trifluoromethylphenoxy)-3 -phenylpropylamine having the general formula (I), where R is hydrogen and the group of the general formula (II), in which R1/s