159263-87-3

Basic information

• Product Name: Benzaldehyde, 2-(acetyloxy)-6-bromo-3-methoxy-
• CAS NO: 159263-87-3
• Molecular Formula: C10H9BrO4
• Molecular Weight: 273.083
• Mol File: 159263-87-3.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: Benzaldehyde, 2-(acetyloxy)-6-bromo-3-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, 2-(acetyloxy)-6-bromo-3-methoxy-(159263-87-3)
• EPA Substance Registry System: Benzaldehyde, 2-(acetyloxy)-6-bromo-3-methoxy-(159263-87-3)

Safety Data

• Hazardous Substances Data: 159263-87-3(Hazardous Substances Data)

Upstream product

• 148-53-8 3-methoxy-2-hydroxybenzaldehyde 
• 7150-01-8 2-acetoxy-3-methoxybenzaldehyde 

Downstream Products

• 158732-59-3 (E)-3-(2-((E)-3,4-dihydroxystyryl)-3,4-dihydroxyphenyl)acrylic acid 
• 83983-71-5 6-bromo-2,3-dihydroxybenzaldehyde 
• 1065559-56-9 (2E)-2-{6-[(E)-2-carboxyvinyl]-2,3-dihydroxyphenyl}-3-(3,4-dihydroxyphenyl) propenoic acid 

Relevant articles and documents

Antineoplastic agents. 443. Synthesis of the cancer cell growth inhibitor hydroxyphenstatin and its sodium diphosphate prodrug

A structure - activity relationship (SAR) study of the South African willow tree (Combretum caffrum) antineoplastic constituent combretastatin A-4 (3b) led to the discovery of a potent cancer cell growth inhibitor designated phenstatin (5a). This benzophenone derivative of combretastatin A-4 showed remarkable antineoplastic activity, and the benzophenone derivative of combretastatin A-1 was therefore synthesized. The benzophenone, designated hydroxyphenstatin (6a), was synthesized by coupling of a protected bromobenzene and a benzaldehyde to give the benzhydrol with subsequent oxidation to the ketone. Hydroxyphenstatin was converted to the sodium phosphate prodrug (6e) by a dibenzyl phosphite phosphorylation and subsequent benzyl cleavage (6a → 6d → 6e). While hydroxyphenstatin (6a) was a potent inhibitor of tubulin polymerization with activity comparable to that of combretastatin A-1 (3a), the phosphorylated derivative (6e) was inactive.

Boron Containing PDE4 Inhibitors

The present invention relates to boron containing compounds of Formula (I) [in-line-formulae]X—Y—Z?? Formula (I)[/in-line-formulae] that inhibit phosphodiesterase 4 (PDE4). The invention also encompasses pharmaceutical compositions containing these compounds and methods for treating diseases, conditions, or disorders ameliorated by inhibition of PDE4.

Synthesis of (+)-salvianolic acid A from sodium Danshensu

(+)-Salvianolic acid A, one of the most active components in the traditional Chinese medicine Danshen, has been synthesized over 10 steps in 6.5% overall yield. Starting from inexpensive ortho-vanillin and sodium Danshensu (synthesized via asymmetric catalysis in our group), the process consists of the following: A Wittig reaction that gives the desire product with absolute E-configuration, a demethylation reaction with AlCl3 in a satisfactory yield, and a practical deprotection of allylic groups to afford the terminal product (+)-salvianolic acid A. The current synthetic technology possesses the advantages of using inexpensive starting materials, mild reaction conditions and has the potential for use in large scale synthesis.