7150-01-8Relevant articles and documents
Overcoming AlbD Protease Resistance and Improving Potency: Synthesis and Bioactivity of Antibacterial Albicidin Analogues with Amide Bond Isosteres
Kleebauer, Leonardo,Zborovsky, Lieby,Hommernick, Kay,Seidel, Maria,Weston, John B.,Süssmuth, Roderich D.
supporting information, p. 7023 - 7027 (2021/09/08)
Albicidin is a potent antibacterial oligoaromatic peptide that is susceptible to the protease AlbD, a resistance factor. This potentially restricts the use of albicidin as a drug. To overcome this obstacle, we synthesized and evaluated six analogues with
The first total synthesis of (±)-methyl salvianolate A using a convergent strategy
Wang, Bo,Wang, Liping,Peng, Ying,Pang, Yiying,Xiao, Hesheng,Wang, Xiaoji,Huang, Shuangping
, (2019/03/19)
Herein, a convergent, practicable and first total synthesis of the natural product, (±)-methyl salvianolate A, is reported. The key features of the approach are the use of a Horner–Wadsworth–Emmons reaction and the protection of multiple hydroxyls using s
Salvianolic acid A intermediate and preparation method thereof
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Paragraph 0038; 0039, (2018/09/08)
The invention relates to a medicine salvianolic acid A intermediate used for treating angina and acute myocardial infarction, i.e., a new synthesis method for trans-3-bromo-2-(3,4-di-substituted styryl)-6-substituted phenol. The method comprises the follo