20035-41-0 Usage
Description
6-Bromo-2-hydroxy-3-methoxybenzaldehyde is a bromobenzaldehyde derivative characterized by the presence of a bromine atom at the 6th position, a hydroxyl group at the 2nd position, and a methoxy group at the 3rd position. It is known for its involvement in the synthesis of various organic compounds and exhibits a monoclinic crystal system with a space group of P21/n.
Uses
Used in Organic Synthesis:
6-Bromo-2-hydroxy-3-methoxybenzaldehyde is used as a key intermediate in the synthesis of complex organic molecules, such as 2-benzyloxy-6-bromo-3-methoxybenzaldehyde and biphenyls. Its unique functional groups and structural features make it a valuable building block for the development of new pharmaceuticals and other organic compounds.
Used in Pharmaceutical Industry:
6-Bromo-2-hydroxy-3-methoxybenzaldehyde is used as a precursor in the synthesis of antihypertensive natural products, specifically S-(+)-XJP and R-(-)-XJP. These natural products have the potential to lower blood pressure and provide therapeutic benefits for individuals suffering from hypertension.
Used in Crystallography Research:
The monoclinic crystal system and space group P21/n of 6-Bromo-2-hydroxy-3-methoxybenzaldehyde's crystals make it an interesting subject for crystallography research. Studying its crystal structure can provide insights into the arrangement of atoms and molecules, which can be useful for understanding the properties and behavior of similar compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 20035-41-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,0,3 and 5 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 20035-41:
(7*2)+(6*0)+(5*0)+(4*3)+(3*5)+(2*4)+(1*1)=50
50 % 10 = 0
So 20035-41-0 is a valid CAS Registry Number.
InChI:InChI=1/C8H7BrO3/c1-12-7-3-2-6(9)5(4-10)8(7)11/h2-4,11H,1H3
20035-41-0Relevant articles and documents
Boron Containing PDE4 Inhibitors
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, (2020/04/29)
The present invention relates to boron containing compounds of Formula (I) [in-line-formulae]X—Y—Z?? Formula (I)[/in-line-formulae] that inhibit phosphodiesterase 4 (PDE4). The invention also encompasses pharmaceutical compositions containing these compounds and methods for treating diseases, conditions, or disorders ameliorated by inhibition of PDE4.
Atropoenantioselective redox-neutral amination of biaryl compounds through borrowing hydrogen and dynamic kinetic resolution
Zhang, Jianwei,Wang, Jian
supporting information, p. 465 - 469 (2017/12/15)
We report herein a novel atropoenantioselective redox-neutral amination of biaryl compounds triggered by a cascade of borrowing hydrogen and dynamic kinetic resolution under the cooperative catalysis of a chiral iridium complex and an achiral Br?nsted acid. This protocol features broad substrate scope and good functional-group tolerance, and allows the rapid assembly of axially chiral biaryl compounds in good to high yields and with high to excellent enantioselectivity.
Ruthenium-Catalyzed Atropoenantioselective Synthesis of Axial Biaryls via Reductive Amination and Dynamic Kinetic Resolution
Guo, Donghui,Zhang, Jianwei,Zhang, Bei,Wang, Jian
supporting information, p. 6284 - 6288 (2018/10/05)
The unprecedented ruthenium-catalyzed atropoenantioselective reductive amination of aldehydes with alkylamines via a cascade transfer hydrogenation and dynamic kinetic resolution strategy is described. This protocol features broad substrate scope and good functional group tolerance and allows the rapid assembly of axially chiral biaryls in good to high yields with high to excellent enantioselectivities. In addition, such structural motifs may have potential applications in enantioselective catalysis as chiral ligands or catalysts.
