1592668-58-0

Basic information

• Product Name: 4-((1-(4-azido-2,3,5,6-tetrafluorophenyl)-1-oxo-6,9,12-trioxa-2-azapentadecan-15-yl)amino)-N₂,N₆-di(quinolin-3-yl)pyridine-2,6-dicarboxamide
• Synonyms: 4-((1-(4-azido-2,3,5,6-tetrafluorophenyl)-1-oxo-6,9,12-trioxa-2-azapentadecan-15-yl)amino)-N₂,N₆-di(quinolin-3-yl)pyridine-2,6-dicarboxamide
• CAS NO: 1592668-58-0
• Molecular Weight: 854.821
• Mol File: 1592668-58-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-((1-(4-azido-2,3,5,6-tetrafluorophenyl)-1-oxo-6,9,12-trioxa-2-azapentadecan-15-yl)amino)-N₂,N₆-di(quinolin-3-yl)pyridine-2,6-dicarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-((1-(4-azido-2,3,5,6-tetrafluorophenyl)-1-oxo-6,9,12-trioxa-2-azapentadecan-15-yl)amino)-N₂,N₆-di(quinolin-3-yl)pyridine-2,6-dicarboxamide(1592668-58-0)
• EPA Substance Registry System: 4-((1-(4-azido-2,3,5,6-tetrafluorophenyl)-1-oxo-6,9,12-trioxa-2-azapentadecan-15-yl)amino)-N₂,N₆-di(quinolin-3-yl)pyridine-2,6-dicarboxamide(1592668-58-0)

Safety Data

• Hazardous Substances Data: 1592668-58-0(Hazardous Substances Data)

Upstream product

• 1592668-46-6 tert-butyl (3-(2-(2-(3-((2,6-bis(quinolin-3-ylcarbamoyl)pyridin-4-yl)amino)propoxy)ethoxy)ethoxy)propyl) carbamate 
• 194920-62-2 tert-butyl N-(3-{2-[2-(3-aminopropoxy)ethoxy]ethoxy}propyl)carbamate 
• 1592668-43-3 4-((3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl)amino)-N₂,N₆-di(quinolin-3-yl)pyridine-2,6-dicarboxamide 
• 122590-77-6 4-azido-2,3,5,6-tetrafluorobenzoic acid 
• 1159206-13-9 4-chloro-N²,N⁶-di(quinolin-3-yl)pyridine-2,6-dicarboxamide 

Relevant articles and documents

Photo-cross-linking probes for trapping G-quadruplex DNA

We have developed a straightforward synthetic pathway to a set of six photoactivatable G-quadruplex ligands with a validated G4-binding motif (the bisquinolinium pyridodicarboxamide PDC-360A) tethered through various spacers to two different photo-cross-linking groups: benzophenone and an aryl azide. The high quadruplex-versus-duplex selectivity of the PDC core was retained in the new derivatives and resulted in selective alkylation of two well-known G-quadruplexes (human telomeric G4 and oncogene promoter c-myc G4) under conditions of harsh competition. The presence of two structurally different photoactivatable functions allowed the selective alkylation of G-quadruplex structures at specific nucleobases and irreversible G4 binding. The topology and sequence of the quadruplex matrix appear to influence strongly the alkylation profile, which differs for the telomeric and c-myc quadruplexes. The new compounds are photoactive in cells and thus provide new tools for studying G4 biology. Catch me if you can: A readily accessible set of photoactivatable G-quadruplex (G4) ligands with a bisquinolinium core showed high G4-versus-duplex selectivity. Alkylation under UV/Vis irradiation occurred at G4 nucleobases located in either the loops or the external G-quartets (see picture), depending on the cross-linker and the topology of the quadruplex. These probes might be used to irreversibly trap G4 structures for the study of G4 biology. Copyright