194920-62-2 Usage
Description
BOC-TOTA, also known as tert-Butyl (3-(2-(2-(3-Aminopropoxy)ethoxy)ethoxy)propyl)carbamate, is a linker containing an amino group with a Boc-protected amino group. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde), etc. The Boc group can be deprotected under mild acidic conditions to form the free amine. It is a versatile molecule with potential applications in various fields due to its unique structure and reactivity.
Uses
Used in Pharmaceutical Industry:
BOC-TOTA is used as a reactant in the synthesis of gallium-labeled PET imaging agents for CXCR4, which are essential for potential cancer diagnosis. Its unique structure allows for the development of targeted imaging agents that can help in the early detection and monitoring of cancer progression.
Used in Chemical Synthesis:
BOC-TOTA is used as a protected linker in chemical synthesis, particularly in the formation of complex molecules and drug candidates. The Boc-protected amino group ensures that the molecule can be selectively deprotected under mild acidic conditions, allowing for the controlled formation of amide bonds and other functional groups without unwanted side reactions.
Used in Drug Delivery Systems:
BOC-TOTA can be employed in the development of drug delivery systems, where its Boc-protected amino group can be utilized to attach drug molecules or targeting ligands to carriers, such as nanoparticles or liposomes. The mild acidic conditions required for Boc deprotection can be tailored to match the acidic environment of tumor tissues, enabling targeted drug release and improved therapeutic outcomes.
Check Digit Verification of cas no
The CAS Registry Mumber 194920-62-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,4,9,2 and 0 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 194920-62:
(8*1)+(7*9)+(6*4)+(5*9)+(4*2)+(3*0)+(2*6)+(1*2)=162
162 % 10 = 2
So 194920-62-2 is a valid CAS Registry Number.
194920-62-2Relevant articles and documents
Flow-mediated synthesis of Boc, Fmoc, and Dd iv monoprotected diamines
Jong, Thingsoon,Bradley, Mark
supporting information, p. 422 - 425 (2015/03/03)
A series of monoprotected aliphatic diamines (21 examples) were synthesized via continuous flow methods. The carbamates and enamines were obtained in 45-91% yields using a 0.5 mm diameter PTFE tubular flow reactor. Using readily accessible protecting group precursors, the procedure serves as an attractive alternative to existing batch-mode synthetic routes by providing direct, multigram access to N-Boc-, N-Fmoc-, and N-Ddiv-protected compounds with productivity indexes of 1.2-3.6 g/h.
Synthesis of a new hydrophilic o-nitrobenzyl photocleavable linker suitable for use in chemical proteomics
Piggott, Andrew M.,Karuso, Peter
, p. 8241 - 8244 (2007/10/03)
Linkers currently used in solid phase synthesis are generally short and hydrophobic, limiting their usefulness in biological systems. Herein, we describe a facile synthesis of a long, hydrophilic, o-nitrobenzyl photocleavable linker, suitable for construc