159581-87-0

Basic information

• Product Name: RA-VII
• Synonyms: RA-VII
• CAS NO: 159581-87-0
• Molecular Weight: 786.949
• Mol File: 159581-87-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: RA-VII(CAS DataBase Reference)
• NIST Chemistry Reference: RA-VII(159581-87-0)
• EPA Substance Registry System: RA-VII(159581-87-0)

Safety Data

• Hazardous Substances Data: 159581-87-0(Hazardous Substances Data)

Upstream product

• 122621-60-7 RA-VII 
• 114234-09-2 2,4-bis(4-methylphenylthio)-1,3,2λ⁵,4λ⁵-dithiadiphosphetane-2,4-dithione 

Downstream Products

• 122621-60-7 RA-VII 
• 333971-05-4 C₄₁H₄₈N₆O₈ 
• 333971-06-5 C₄₁H₄₈N₆O₈ 

Relevant articles and documents

Studies on Rubia Akane (RA) derivatives. Part 10. Backbone transformation of RA-VII, an antitumour cyclic hexapeptide, through thionation. X-ray crystal structure of [Tyr-3-ψ(CH2NH)-Ala-4]RA-VII

RA-VII 1 was thionated with Davy reagent methyl 6 or Davy reagent p-tolyl 7 to afford novel thionopeptides, [Tyr-6-ψ(CS-NH)-D-Ala-1]RA-VII 8, [D-Ala-1-ψ(CS-NH)-Ala-2; Tyr-3-ψ(CS-NH)-Ala-4]RA-VII 9 and [Ala-2-ψ(CS-NH)-Tyr-3; Tyr-3-ψ(CS-NH)-Ala-4]RA-VII 10 in addition to known analogues [Tyr-3-ψ(CS-NH)-Ala-4]RA-VII 4 and [Tyr-3-ψ(CS-NH)-Ala-4; Tyr-6-ψ(CS-NH)-D-Ala-1]RA-VII 5. Thionopeptide 4 was reduced with nickel borohydride to give reduced peptide 11. An X-ray analysis and an NMR study revealed that compound 11 adopts a different conformation within the 18-membered-ring moiety from the predominant solution conformation of peptide 1 and of thionopeptides 4, 5, 8-10, which would explain the loss in activity of compound 11.

Studies on Rubia akane (RA) Derivatives. Part 7. Thioamide Analogues of RAs: Antitumour Cyclic Hexapeptides

RA-VII 3, RA-VII 4, RA-V 7 and RA-X methyl ester 8 have been prepared from corresponding RAs, and they showed more promising in vitro antitumo