159581-88-1Relevant articles and documents
Synthesis of [L-Ala-1]RA-VII, [D-Ala-2]RA-VII, and [D-Ala-4]RA-VII by epimerization of RA-VII, an antitumor bicyclic hexapeptide from rubia plants, through oxazoles
Hitotsuyanagi, Yukio,Sasaki, Shin-ichi,Matsumoto, Yuji,Yamaguchi, Kentaro,Itokawa, Hideji,Takeya, Koichi
, p. 7284 - 7290 (2007/10/03)
Three epimers of a natural cyclic hexapeptide RA-VII were prepared via formation of oxazoles from thioamides or thioimidates of RA-VII followed by hydrolysis. They are the epimers at L-Ala-1, D-Ala-2, and D-Ala-4, respectively. The one having L-Ala-1 adop
Studies on Rubia akane (RA) Derivatives. Part 7. Thioamide Analogues of RAs: Antitumour Cyclic Hexapeptides
Hitotsuyanagi, Yukio,Suzuki, Jin,Matsumoto, Yuji,Takeya, Koichi,Itokawa, Hideji
, p. 1887 - 1890 (2007/10/02)
RA-VII 3, RA-VII 4, RA-V 7 and RA-X methyl ester 8 have been prepared from corresponding RAs, and they showed more promising in vitro antitumo