159679-68-2

Basic information

• Product Name: (2-Phenyl-imidazo[1,2-a]pyridin-3-yl)-methanol
• Synonyms: (2-Phenyl-imidazo[1,2-a]pyridin-3-yl)-methanol;Imidazo[1,2-a]pyridine-3-methanol, 2-phenyl-
• CAS NO: 159679-68-2
• Molecular Formula: C14H12N2O
• Molecular Weight: 224.25788
• Mol File: 159679-68-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 211-212 °C
• Appearance: /
• Density: 1.21±0.1 g/cm3(Predicted)
• PKA: 13.95±0.10(Predicted)
• CAS DataBase Reference: (2-Phenyl-imidazo[1,2-a]pyridin-3-yl)-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2-Phenyl-imidazo[1,2-a]pyridin-3-yl)-methanol(159679-68-2)
• EPA Substance Registry System: (2-Phenyl-imidazo[1,2-a]pyridin-3-yl)-methanol(159679-68-2)

Safety Data

• Hazardous Substances Data: 159679-68-2(Hazardous Substances Data)

Usage

Description

(2-Phenyl-imidazo[1,2-a]pyridin-3-yl)-methanol is a chemical compound with the molecular formula C14H12N2O. It is classified as an imidazo[1,2-a]pyridine derivative and contains a phenyl group attached to the imidazo[1,2-a]pyridin-3-yl core. (2-Phenyl-imidazo[1,2-a]pyridin-3-yl)-methanol has potential biological and pharmaceutical activities due to its structure and properties.
Used in Medicinal Chemistry Research:
(2-Phenyl-imidazo[1,2-a]pyridin-3-yl)-methanol is used as a research compound for the development of new drugs targeting specific biological pathways or interactions. Its unique structure and properties make it a promising candidate for medicinal chemistry research.
Used in Synthesis of Organic Compounds:
(2-Phenyl-imidazo[1,2-a]pyridin-3-yl)-methanol can also serve as a starting material for the synthesis of other organic compounds with similar structural characteristics. This allows for the exploration of new chemical entities and potential applications in various fields.
Further studies and testing are required to determine the full range of applications and potential uses for (2-Phenyl-imidazo[1,2-a]pyridin-3-yl)-methanol.

Upstream product

• 4105-21-9 2-phenylimidazo[1,2-a]pyridine 
• 98-86-2 acetophenone 
• 3672-39-7 2-phenylimidazo[1,2-a]pyridine-3-carbaldehyde 
• 70-11-1 α-bromoacetophenone 
• 1314079-01-0 N-(1-phenylallyl)-2-aminopyridine 
• 67-56-1 methanol 
• 504-29-0 2-aminopyridine 
• 107-21-1 ethylene glycol 
• 56-81-5 glycerol 

Relevant articles and documents

KIO4-mediated Selective Hydroxymethylation/Methylenation of Imidazo-Heteroarenes: A Greener Approach

Herein, we report a KIO4-mediated, sustainable and chemoselective approach for the one-pot C(sp2)?H bond hydroxymethylation or methylenation of imidazo-heteroarenes with formaldehyde, generated in situ via the oxidative cleavage of ethylene glycol or glycerol (renewable reagents) through the Malaprade reaction. In the presence of ethylene glycol, a series of 3-hydroxymethyl-imidazo-heteroarenes was obtained in good to excellent yields. These compounds are important intermediates to access pharmaceutical drugs, e.g., Zolpidem. Furthermore, by using glycerol, bis(imidazo[1,2-a]pyridin-3-yl)methane derivatives were selectively obtained in good to excellent yields.

Oxidative sulfonamidomethylation of imidazopyridines utilizing methanol as the main C1 source

An efficient one pot, three component synthesis of C3 sulfonamidomethylated imidazopyridines has been disclosed under metal-free conditions, which utilized the commercially available and renewable reagent methanol as the main methylene source. A wide range of substituted imidazopyridines and sulfamides/amines were well tolerated to afford the corresponding products in up to 92% yield. In the isotopic labelling experiment, it was found that a minor part of the methylene also originated from DTBP. Moreover, the radical scavenger reactions were conducted, which suggested that a free-radical mechanism was probably not involved. The current methodology featured several advantages, including broad substrate scope, good functional group tolerance and high reaction efficiency.

Exploration of the CuAAC reaction for the synthesis of novel 3-(triazol-1-yl)methyl-imidazo[1,2-a]pyridines

The archetypical CuAAC click chemistry is explored to assemble diverse 3-(triazol-1-yl)methyl-imidazo[1,2-a]pyridines. The approach is simple, general, and environmentally benign to generate a library of novel triazolo-imidazo[1,2- a]pyridine derivatives in good yield (30-90%).