3672-39-7

Basic information

• Product Name: 2-PHENYL-IMIDAZO[1,2-A]PYRIDINE-3-CARBALDEHYDE
• Synonyms: 2-PHENYL-IMIDAZO[1,2-A]PYRIDINE-3-CARBALDEHYDE;IFLAB-BB F1912-0019;AURORA KA-4206;2-phenyl-3-imidazo[3,2-a]pyridinecarboxaldehyde;2-phenylimidazo[3,2-a]pyridine-3-carbaldehyde;Imidazo[1,2-a]pyridine-3-carboxaldehyde, 2-phenyl-
• CAS NO: 3672-39-7
• Molecular Formula: C₁₄H₁₀N₂O
• Molecular Weight: 222.24
• Mol File: 3672-39-7.mol
• Article Data: 29

Chemical Properties

• Appearance: /
• Density: 1.19g/cm³
• Refractive Index: 1.646
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-PHENYL-IMIDAZO[1,2-A]PYRIDINE-3-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PHENYL-IMIDAZO[1,2-A]PYRIDINE-3-CARBALDEHYDE(3672-39-7)
• EPA Substance Registry System: 2-PHENYL-IMIDAZO[1,2-A]PYRIDINE-3-CARBALDEHYDE(3672-39-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 3672-39-7(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 24, p. 5599, 1983 DOI: 10.1016/S0040-4039(00)94151-0

InChI:InChI=1/C14H10N2O/c17-10-12-14(11-6-2-1-3-7-11)15-13-8-4-5-9-16(12)13/h1-10H

Upstream product

• 89021-05-6 pyridin-3-yl)methyl>phosphonsaeure-diisopropylester 
• 74944-13-1 2,2,2-trichloro-1-(2-phenyl-imidazo[1,2-a]pyridin-3-yl)-ethanol 
• 504-29-0 2-aminopyridine 
• 70508-79-1 (E)-3-Oxo-3-phenyl-1-propenyl-phosphonsaeure-diisopropylester 
• 84542-96-1 trans-1,2-Epoxy-3-oxo-3-phenylprop-1-ylphosphonsaeurediisopropylester 
• 4105-21-9 2-phenylimidazo[1,2-a]pyridine 
• 89020-99-5 (3-Benzoyl-oxiranyl)-phosphonic acid diisopropyl ester 
• 292638-85-8 acrylic acid methyl ester 
• 1883-96-1 N-benzylidenepyridin-2-amine 
• 1314079-01-0 N-(1-phenylallyl)-2-aminopyridine 
• 100-52-7 benzaldehyde 
• 68-12-2 N,N-dimethyl-formamide 
• 98-86-2 acetophenone 
• 70-11-1 α-bromoacetophenone 

Downstream Products

• 119448-82-7 ethyl 2-phenylimidazo[1,2-a] pyridine-3-carboxylate 
• 723341-56-8 4-[(E)-2-(2-phenylimidazo[1,2-a]pyridin-3-yl)vinyl]pyrimidin-2-amine 
• 159679-68-2 (2-phenyl-1H-imidazo[1,2-a]pyridin-3-yl)methanol 
• 1417910-23-6 3-(azidomethyl)-2-phenyl-1H-imidazo[1,2-a]pyridine 
• 1417910-32-7 2-phenyl-3-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)-1H-imidazo[1,2-a]pyridine 
• 1417910-33-8 2-phenyl-3-((4-p-tolyl-1H-1,2,3-triazol-1-yl)methyl)-1H-imidazo[1,2-a]pyridine 

Relevant articles and documents

Inhibitive effect of imidazopyridine derivative towards corrosion of C38 steel in hydrochloric acid solution

The effect of adding 2-phenylimidazo[1,2-a]pyridine-3-carbaldehyde derivative named (P2), newly synthesized on the electrochemical behavior of C38 steel in molar hydrochloric acid was investigated by using the weight-loss method, potentiodynamic polarization, and electrochemical impedance spectroscopy (EIS) measurements. EIS results show that the transfer resistance increases with the increase of concentration of P2 and it also had an inhibiting effect on C38 steel corrosion in HCl solutions. Weight-loss essays confirm that the corrosion rate decreases as the P2 concentration increases. The inhibition efficiency for this compound studied increased with the increase in the inhibitor concentrations to attain 91.7 % at the 10-3 M of P2. The potentiodynamic polarization curves indicated that P2 acted as a mixed-type inhibitor in hydrochloric acid.

Gluconic acid promoted cascade reactions of 2-phenylimidazo[1,2-a] pyridine-3-carbaldehyde with cyclohexane-1,3-dione to create novel fused bisheterocycles

Here in, we described the synthesis of novel bisheterocycles imidazopyridine bearing xanthenedione by reacting various substituted 2-phenylimidazo [1,2-a] pyridine-3-carbaldehyde with cyclohexane-1,3-dione in gluconic acid aqueous solution (GAAS) via a ta

Synthesis, Molecular Docking, BSA, and In Vitro Reactivation Study of Imidazopyridine Oximes Against Paraoxon Inhibited Acetylcholinesterase

Aim: To synthesize and evaluate the fused heterocyclic imidazo[1,2-a]pyridine based oxime as a reactivator against paraoxon inhibited acetylcholinesterase. Background: Organophosphorus compounds (OPs) include parathion, malathion, chlorpyrifos, monocrotop

Metal-free oxidative decarbonylative halogenation of fused imidazoles

An efficient strategy has been developed for the deformylative halogenation of carbaldehyde imidazo-fused heterocycles in the presence of TBHP controlled by temperature. A convenient and sequential functionalization (C8 to C3) portrays the synthetic utility of the current method.N-Heterocycle benzamide products were also observedviathe ring opening of imidazopyridines through the cleavage of C-C bond at high temperatures. Features of this method include temperature-controlled excellent regioselectivity, mild conditions and functional group tolerance.

Copper- A nd DMF-mediated switchable oxidative C-H cyanation and formylation of imidazo[1,2-: A] pyridines using ammonium iodide

The cyanation and formylation of imidazo[1,2-a]pyridines were developed under copper-mediated oxidative conditions using ammonium iodide and DMF as a nontoxic combined cyano-group source and DMF as a formylation reagent. Mechanistic studies indicate that the cyanation of imidazo[1,2-a]pyridines proceeds through a two-step sequence: Initial iodination and then cyanation. The cyanation has a broad substrate scope and high functional group tolerance, and can be safely conducted on a gram scale. A novel copper-mediated formylation using the widely available DMF as the formylation reagent and environmentally friendly molecular oxygen as the oxidant has also been developed. This protocol also provided a convenient approach for the synthesis of clinically used saripidem. This journal is