723341-56-8Relevant articles and documents
Discovery of imidazole vinyl pyrimidines as a novel class of kinase inhibitors which inhibit Tie-2 and are orally bioavailable
Buttar, David,Edge, Mike,Emery, Steve C.,Fitzek, Martina,Forder, Cheryl,Griffen, Alison,Hayter, Barry,Hayward, Chris F.,Hopcroft, Philip J.,Luke, Richard W.A.,Page, Ken,Stawpert, John,Wright, Andy
scheme or table, p. 4723 - 4726 (2009/04/06)
Tie-2 is a receptor tyrosine kinase which is involved in angiogenesis and thereby growth of human tumours. The discovery and SAR of a novel class of imidazole-vinyl-pyrimidine kinase inhibitors, which inhibit Tie-2 in vitro is reported. Their synthesis wa
