1417910-32-7

Basic information

• Product Name: 2-phenyl-3-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)-1H-imidazo[1,2-a]pyridine
• Synonyms: 2-phenyl-3-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)-1H-imidazo[1,2-a]pyridine
• CAS NO: 1417910-32-7
• Molecular Weight: 351.41
• Mol File: 1417910-32-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-phenyl-3-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)-1H-imidazo[1,2-a]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyl-3-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)-1H-imidazo[1,2-a]pyridine(1417910-32-7)
• EPA Substance Registry System: 2-phenyl-3-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)-1H-imidazo[1,2-a]pyridine(1417910-32-7)

Safety Data

• Hazardous Substances Data: 1417910-32-7(Hazardous Substances Data)

Upstream product

• 70-11-1 α-bromoacetophenone 
• 3672-39-7 2-phenylimidazo[1,2-a]pyridine-3-carbaldehyde 
• 159679-68-2 (2-phenyl-1H-imidazo[1,2-a]pyridin-3-yl)methanol 
• 98-86-2 acetophenone 
• 4105-21-9 2-phenylimidazo[1,2-a]pyridine 

Relevant articles and documents

KIO4-mediated Selective Hydroxymethylation/Methylenation of Imidazo-Heteroarenes: A Greener Approach

Herein, we report a KIO4-mediated, sustainable and chemoselective approach for the one-pot C(sp2)?H bond hydroxymethylation or methylenation of imidazo-heteroarenes with formaldehyde, generated in situ via the oxidative cleavage of ethylene glycol or glycerol (renewable reagents) through the Malaprade reaction. In the presence of ethylene glycol, a series of 3-hydroxymethyl-imidazo-heteroarenes was obtained in good to excellent yields. These compounds are important intermediates to access pharmaceutical drugs, e.g., Zolpidem. Furthermore, by using glycerol, bis(imidazo[1,2-a]pyridin-3-yl)methane derivatives were selectively obtained in good to excellent yields.