84542-96-1

Basic information

• Product Name: cis-1,2-Epoxy-3-oxo-3-phenylprop-1-ylphosphonsaeurediisopropylester
• CAS NO: 84542-96-1
• Molecular Weight: 312.303
• Mol File: 84542-96-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: cis-1,2-Epoxy-3-oxo-3-phenylprop-1-ylphosphonsaeurediisopropylester(CAS DataBase Reference)
• NIST Chemistry Reference: cis-1,2-Epoxy-3-oxo-3-phenylprop-1-ylphosphonsaeurediisopropylester(84542-96-1)
• EPA Substance Registry System: cis-1,2-Epoxy-3-oxo-3-phenylprop-1-ylphosphonsaeurediisopropylester(84542-96-1)

Safety Data

• Hazardous Substances Data: 84542-96-1(Hazardous Substances Data)

Upstream product

• 70508-79-1 (E)-3-Oxo-3-phenyl-1-propenyl-phosphonsaeure-diisopropylester 
• 84542-62-1 1,2-Dihydroxy-3-oxo-3-phenylprop-1-ylphosphonsaeurediisopropylester 

Downstream Products

• 89021-05-6 pyridin-3-yl)methyl>phosphonsaeure-diisopropylester 
• 89021-09-0 pyrimidin-3-yl)methyl>phosphonsaeure-diisopropylester 
• 100289-27-8 3-<(Diisopropoxyphosphinyl)hydroxymethyl>-2-phenylimidazo<1,2-c>pyrimidin-5(6H)-on 
• 89021-02-3 <(2-Amino-4-phenyl-5-thiazolyl)hydroxymethyl>phosphonsaeure-diisopropylester 
• 134891-87-5 diisopropyl <(2,4-diphenyl-5-thiazolyl)hydroxymethyl>phosphonate 
• 32623-28-2 2-amino-4-phenyl-1,3-thiazole-5-carboxaldehyde 
• 89021-22-7 3-Formyl-2-phenyl-1-indolizincarbonsaeure-ethylester 
• 74944-29-9 2-Phenylimidazo<1,2-a>pyrimidin-3-carboxaldehyd 
• 3672-39-7 2-phenylimidazo[1,2-a]pyridine-3-carbaldehyde 
• 134891-91-1 (2,4-Diphenyl-thiazol-5-ylmethyl)-phosphonic acid diisopropyl ester 
• 134891-85-3 [(2,4-Diphenyl-thiazol-5-yl)-methylsulfanyl-methyl]-phosphonic acid diisopropyl ester 
• 134891-80-8 [(2,4-Diphenyl-thiazol-5-yl)-p-tolyloxycarbonylsulfanyl-methyl]-phosphonic acid diisopropyl ester 
• 134891-75-1 [(2,4-Diphenyl-thiazol-5-yl)-p-tolyloxythiocarbonyloxy-methyl]-phosphonic acid diisopropyl ester 

Relevant articles and documents

Dialkyl (1,2-Epoxy-3-oxoalkyl)phosphonates as Synthons for Heterocyclic Carbonyl Compounds: Synthesis of Acyl-Substituted Thiazoles, Indolizines, Imidazopyridines and Imidazopyrimidines

Dialkyl phosphonates (1) react with H2O2/Na2CO3 to give the corresponding trans-1,2-epoxy derivatives 2.These, on reaction with thioamides 4-7, afford (1-hydroxy-1-thiazolylalkyl)phosphonates 8-11, with ethyl α-pyridylacetate (indolizinylalkyl)phosphonates 19, with 2-aminopyridine (imidazopyridinylalkyl)phosphonates 20 (together with the α-amino compounds 22) and with 2-aminopyrimidine the (imidazopyrimidinylalkyl)phosphonates 21.On treatment with alkali or by pyrolysis the (1-hetaryl-1-hydroxyalkyl)phosphonates 9-11 and 19-21 yield the corresponding acyl-substituted heterocycles (thiazoles 13-15 and bicyclic acyl compounds 23-25). - The structure of the bicyclic derivatives 19-25 is assigned from the considerable deshielding of their 5-H NMR signals caused by the electron-rich substituents in peri-3-position.Condensation of the epoxyketones 2 with cytosine results in the isomeric (imidazopyrimidinylalkyl)phosphonates 27 and 28, which can be cleaved to the corresponding aldehydes 29 and 30, respectively.