159770-30-6Relevant articles and documents
1,3-Dipolar cycloaddition route to nitrogen heterocyclic triones
Jones, Raymond C. F.,Bhalay, Gurdip,Carter, Paul A.,Duller, Kathryn A. M.,Dunn, Stephen H.
, p. 765 - 776 (2007/10/03)
1,3-Dipolar cycloaddition of nitrile oxides, formed in situ by dehydration of primary nitro compounds, with pyrrolidine enamines of protected γ- or δ-amino-β-keto esters affords isoxazole-4-carboxylates; these undergo lactam formation and N-O bond cleavage to afford 3-acyltetramic acids and 3-acyl-4-hydroxypyridin-2-ones.