159884-50-1Relevant articles and documents
Enantioselective synthesis of AG-041R by using N-heteroarenesulfonyl cinchona alkaloid amides as organocatalysts
Hara, Noriyuki,Nakamura, Shuichi,Sano, Masahide,Tamura, Ryota,Funahashi, Yasuhiro,Shibata, Norio
, p. 9276 - 9280 (2012)
The organocatalytic enantioselective decarboxylative addition of malonic acid half thioesters to ketimines derived from isatins by using N-heteroarenesulfonyl cinchona alkaloid amides afforded products with high enantioselectivity. The products could be c
Efficient asymmetric synthesis of novel gastrin receptor antagonist AG-041R via highly stereoselective alkylation of oxindole enolates
Emura, Takashi,Esaki, Toru,Tachibana, Kazutaka,Shimizu, Makoto
, p. 8559 - 8564 (2007/10/03)
An efficient method for asymmetric synthesis of the potent Gastrin/CCK-B receptor antagonist AG-041R was developed. Core oxindole stereochemistry was established by asymmetric alkylation of oxindole enolates with bromoacetic acid esters, using l-menthol a