199800-49-2

Basic information

• Product Name: AG-041R
• Synonyms: AG-041R;AG-041R Exclusive
• CAS NO: 199800-49-2
• Molecular Formula: C31H36N4O5
• Molecular Weight: 544.64134
• Mol File: 199800-49-2.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 766.592°C at 760 mmHg
• Flash Point: 417.42°C
• Appearance: /
• Density: 1.259g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.625
• CAS DataBase Reference: AG-041R(CAS DataBase Reference)
• NIST Chemistry Reference: AG-041R(199800-49-2)
• EPA Substance Registry System: AG-041R(199800-49-2)

Safety Data

• Hazardous Substances Data: 199800-49-2(Hazardous Substances Data)

Usage

Description

AG-041R is a potent gastrin/CCKB receptor antagonist, characterized by its selective binding for the cholecystokinin B (CCKB) receptor over the cholecystokinin A (CCKA) receptor. This selective binding property makes AG-041R a valuable compound in various applications, particularly in the pharmaceutical and medical fields.

Uses

Used in Pharmaceutical Industry:
AG-041R is used as a therapeutic agent for the treatment of conditions related to the overactivation of the CCKB receptor. Its selective binding to the CCKB receptor helps in modulating the effects of cholecystokinin, a hormone that plays a role in various physiological processes, including digestion and the regulation of satiety.
Used in Research and Development:
In the field of research, AG-041R is utilized as a research tool to study the role of CCKB receptors in various biological processes and diseases. Its selective binding property allows scientists to investigate the specific functions and interactions of the CCKB receptor, leading to a better understanding of its role in the body and the development of targeted therapies.
Used in Cancer Treatment:
AG-041R has been found to have potential applications in cancer treatment, particularly in the context of tumors that overexpress CCKB receptors. By blocking the CCKB receptor, AG-041R may help in inhibiting tumor growth and progression, making it a promising candidate for the development of targeted cancer therapies.
Used in Gastrointestinal Disorders:
AG-041R is used as a treatment option for gastrointestinal disorders that involve the overactivation of the CCKB receptor, such as irritable bowel syndrome (IBS) and gastroesophageal reflux disease (GERD). By selectively blocking the CCKB receptor, AG-041R can help in reducing the symptoms associated with these conditions and improve the quality of life for patients.

InChI:InChI=1/C31H36N4O5/c1-5-39-28(40-6-2)20-35-26-10-8-7-9-25(26)31(29(35)37,19-27(36)32-23-15-11-21(3)12-16-23)34-30(38)33-24-17-13-22(4)14-18-24/h7-18,28H,5-6,19-20H2,1-4H3,(H,32,36)(H2,33,34,38)/t31-/m1/s1

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Relevant articles and documents

Catalytic Enantioselective Decarboxylative Mannich-Type Reaction of N-Unprotected Isatin-Derived Ketimines

The first catalytic enantioselective decarboxylative Mannich-type reaction of N-unprotected ketimines is reported, directly providing N-unprotected 3-tetrasubstituted 3-aminooxindoles in high yield and ee without protection/deprotection steps. The utility

An asymmetric acetate-Mannich reaction of chiral isatin derived ketimines and its applications

A highly efficient TMSOTf-mediated asymmetric acetate-Mannich reaction of isatin derived tert-butylsulfinyl ketimines and S-phenyl thioacetate was developed to afford the direct synthesis of indole-based β3,3-amino acid thioester with excellent selectivity (dr > 98 : 2). Syntheses of (+)-AG-041R and 3-aminopyrroloindoline have been accomplished utilizing the developed method.

Enantioselective synthesis of AG-041R by using N-heteroarenesulfonyl cinchona alkaloid amides as organocatalysts

The organocatalytic enantioselective decarboxylative addition of malonic acid half thioesters to ketimines derived from isatins by using N-heteroarenesulfonyl cinchona alkaloid amides afforded products with high enantioselectivity. The products could be c