1600535-47-4

Basic information

• Product Name: [(4-bromophenyl)hydroxy(hydroxyphenoxyphosphoryl)methyl]phosphonic acid
• CAS NO: 1600535-47-4
• Molecular Weight: 423.094
• Mol File: 1600535-47-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [(4-bromophenyl)hydroxy(hydroxyphenoxyphosphoryl)methyl]phosphonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: [(4-bromophenyl)hydroxy(hydroxyphenoxyphosphoryl)methyl]phosphonic acid(1600535-47-4)
• EPA Substance Registry System: [(4-bromophenyl)hydroxy(hydroxyphenoxyphosphoryl)methyl]phosphonic acid(1600535-47-4)

Safety Data

• Hazardous Substances Data: 1600535-47-4(Hazardous Substances Data)

Upstream product

• 33493-31-1 p-Brombenzoyl-dimethyl-phosphonat 
• 586-75-4 4-chlorobenzoyl chloride 

Relevant articles and documents

Bisphosphonate prodrugs: Synthesis and biological evaluation in HuH7 hepatocarcinoma cells

We investigated the biological effects of new synthesized bisphosphonates (BPs) on HuH7 hepatocarcinoma cells. BPs containing p-bromophenyl (R1 = p-Br, Ph, 2) in their side chain were the more potent to inhibit HuH7 cell viability. In addition, phenyl diesterified analogues (R2 = R 3 = Ph, 2a) were more potent than methyl (R2 = R 3 = Me, 2b) or non-esterified BPs (2) inducing more necrosis suggesting that they better entered into cells. Phosphodiesterase inhibitor (IBMX) reversed the effect of the esterified BPs and not that of non-esterified ones suggesting role of cell phosphodiesterases to release active BPs. BP analogues inhibited HuH7 cell migration but esterified ones had no effect on invasion due to the hiding of phosphonic groups. All together, these results indicated the therapeutic interest of these new BP prodrugs.