1601370-01-7

Basic information

• Product Name: 3-bromo-5-methoxy-2-((4-trifluoromethylphenyl)ethyl)cyclohexa-2,5-diene-1,4-dione
• Synonyms: 3-bromo-5-methoxy-2-((4-trifluoromethylphenyl)ethyl)cyclohexa-2,5-diene-1,4-dione
• CAS NO: 1601370-01-7
• Molecular Weight: 389.169
• Mol File: 1601370-01-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-bromo-5-methoxy-2-((4-trifluoromethylphenyl)ethyl)cyclohexa-2,5-diene-1,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 3-bromo-5-methoxy-2-((4-trifluoromethylphenyl)ethyl)cyclohexa-2,5-diene-1,4-dione(1601370-01-7)
• EPA Substance Registry System: 3-bromo-5-methoxy-2-((4-trifluoromethylphenyl)ethyl)cyclohexa-2,5-diene-1,4-dione(1601370-01-7)

Safety Data

• Hazardous Substances Data: 1601370-01-7(Hazardous Substances Data)

Upstream product

• 23030-47-9 2-bromo-6-methoxycyclohexa-2,5-diene-1,4-dione 
• 53473-36-2 3-(4-trifluoromethylphenyl)propionic acid 
• 61654-67-9 2,5-dihydroxy-3-methoxy-1-bromobenzene 
• 2973-76-4 5-bromo-4-hydroxy-3-methoxybenzaldehyde 

Relevant articles and documents

Facile construction of 3-hydroxyphenanthrene-1,4-diones: Key intermediates to tanshinone i and its A-ring-modified analogue

A mild synthetic approach was established allowing for a convenient construction of tricyclic hydroxyphenanthraquinones, the key precursor for total synthesis of tanshinone I. This tandem process includes decarboxylative radical alkylation, intramolecular C-H arylation and one-pot O-demethylation and aromatization. Variously substituted phenylpropanoic acids were well tolerated in this approach, and synthesis of tanshinone I (1) was finally successful in six straight steps in 19% overall yields from commercially available 5-bromovanillin.