160376-91-0

Basic information

• Product Name: 1-tert-butoxycarbonyl-4-phenyl-4[[(3,5-bis-trifluoromethyl)]benzyloxymethyl]piperidine
• Synonyms: 1-tert-butoxycarbonyl-4-phenyl-4[[(3,5-bis-trifluoromethyl)]benzyloxymethyl]piperidine
• CAS NO: 160376-91-0
• Molecular Weight: 517.512
• Mol File: 160376-91-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-tert-butoxycarbonyl-4-phenyl-4[[(3,5-bis-trifluoromethyl)]benzyloxymethyl]piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-tert-butoxycarbonyl-4-phenyl-4[[(3,5-bis-trifluoromethyl)]benzyloxymethyl]piperidine(160376-91-0)
• EPA Substance Registry System: 1-tert-butoxycarbonyl-4-phenyl-4[[(3,5-bis-trifluoromethyl)]benzyloxymethyl]piperidine(160376-91-0)

Safety Data

• Hazardous Substances Data: 160376-91-0(Hazardous Substances Data)

Upstream product

• 32247-96-4 3,5-bis(trifluoromethyl)benzyl bromide 
• 158144-85-5 1-t-butoxycarbonyl-4-phenyl-4-hydroxymethyl piperidine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 3627-45-0 4-phenyl-piperidine-4-carboxylic acid 
• 4220-08-0 (4-phenyl-piperidin-4-yl)-methanol 

Downstream Products

• 160375-92-8 4-phenyl-4-[3,5-(bistrifluoromethyl)-benzyloxymethyl]piperidine 

Relevant articles and documents

1-AMIDO-4-PHENYL-4-BENZYLOXYMETHYL-PIPERIDINE DERIVATIVES AND RELATED COMPOUNDS AS NEUROKININ-1(NK-1) ANTAGONISTS FOR THE TREATMENT OF EMESIS, DEPRESSION, ANXIETY AND COUGH

Disclosed are NK1 antagonists having the formula: Also disclosed are uses of compounds of formula (I) for the manufacture of a medicament for treating a number of physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough.

4-Arylmethyloxymethyl piperidines as tachykinin antagonsits

The present invention is directed to compounds of the formula (I) STR1 wherein R1, R2, R3, R4, R5, R6, and R7 are defined herein, and pharmaceutically acceptable salts thereof, w