3627-45-0

Basic information

• Product Name: 4-PHENYL-4-PIPERIDINE CARBOXYLIC ACID
• Synonyms: 4-phenyl-4-piperidinecarboxylicaci;4-phenyl-isonipecoticaci;4-phenylpiperidine-4-carboxylicacid;n-demthylmeperidinicacid;normeperidinicacid;4-PHENYL-4-PIPERIDINE CARBOXYLIC ACID;4-Phenyl-4-piperidinecarboxylic acid HCl;Norpethidinic acid
• CAS NO: 3627-45-0
• Molecular Formula: C₁₂H₁₅NO₂
• Molecular Weight: 205.25
• EINECS: 222-844-0
• Product Categories: pharmacetical
• Mol File: 3627-45-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 374.9 °C at 760 mmHg
• Flash Point: 180.5 °C
• Appearance: /
• Density: 1.157 g/cm³
• Vapor Pressure: 2.75E-06mmHg at 25°C
• Refractive Index: 1.554
• CAS DataBase Reference: 4-PHENYL-4-PIPERIDINE CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PHENYL-4-PIPERIDINE CARBOXYLIC ACID(3627-45-0)
• EPA Substance Registry System: 4-PHENYL-4-PIPERIDINE CARBOXYLIC ACID(3627-45-0)

Safety Data

• Hazardous Substances Data: 3627-45-0(Hazardous Substances Data)

Usage

Uses

4-Phenyl-4-piperidine carboxylic Acid is used to prepare CB1 antagonists with lowered propensity to pass the blood-brain-barrier. It is also used to synthesize 4,4-disubstituted piperidines as NK1 antagonists.

InChI:InChI=1/C12H15NO2/c14-11(15)12(6-8-13-9-7-12)10-4-2-1-3-5-10/h1-5,13H,6-9H2,(H,14,15)

Upstream product

• 24476-55-9 N-(p-tosyl)-4-phenyl-4-cyano-piperidine 
• 28233-54-7 1-cyano-4-phenyl-piperidine-4-carboxylic acid ethyl ester 
• 57-42-1 pethidine 
• 181641-61-2 1-((benzyloxy)carbonyl)-4-phenylpiperidine-4-carboxylic acid 
• 922504-27-6 4-benzoylpiperidine-1-carboxylic acid benzyl ester 
• 916976-36-8 4-benzhydrylidene-piperidine-1-carboxylic acid benzyl ester 
• 916976-41-5 4-benzoyl-4-phenyl-piperidine-1-carboxylic acid benzyl ester 
• 96067-93-5 benzyl 4-(hydroxydiphenylmethyl)-piperidine-1-carboxylate 
• 37586-22-4 4-benzoylpiperidine 
• 140-29-4 phenylacetonitrile 
• 51304-58-6 4-cyano-4-phenylpiperidine hydrochloride 
• 167262-68-2 N-(t-butyloxycarbonyl)-4-phenylpiperidine-4-carboxylic acid 
• 61886-17-7 1-benzyl-4-phenyl-piperidine-4-carboxylic acid 
• 101-41-7 benzeneacetic acid methyl ester 

Downstream Products

• 158144-85-5 1-t-butoxycarbonyl-4-phenyl-4-hydroxymethyl piperidine 
• 4220-08-0 (4-phenyl-piperidin-4-yl)-methanol 
• 160376-91-0 1-tert-butoxycarbonyl-4-phenyl-4[[(3,5-bis-trifluoromethyl)]benzyloxymethyl]piperidine 
• 1027259-36-4 4-Benzyloxymethyl-4-phenyl-piperidine-1-carboxylic acid tert-butyl ester 
• 1026630-76-1 4-(3,5-Dimethyl-benzyloxymethyl)-4-phenyl-piperidine-1-carboxylic acid tert-butyl ester 
• 1026458-87-6 4-(3,5-Dichloro-benzyloxymethyl)-4-phenyl-piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

The role of analgesic drug metabolites in the formation of lens opacities.

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Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities

A new series of thiazole-substituted 1,1,1,3,3,3-hexafluoro-2-propanols were prepared and evaluated as malonyl-CoA decarboxylase (MCD) inhibitors. Key analogs caused dose-dependent decreases in food intake and body weight in obese mice. Acute treatment with these compounds also led to a drop in elevated blood glucose in a murine model of type II diabetes.

CAN-mediated rearrangement of 4-benzhydrylidenepiperidines

Several 1-substituted phenyl-(4-phenylpiperidin-4-yl)methanones are synthesized in modest overall yields starting from the reaction of different 1-substituted 4-benzhydrylidenepiperidines via CAN-mediated rearrangement. This facile strategy was also used to synthesize meperidine analog.