1605-65-8 Usage
Description
Bis(dimethylamino)phosphoryl chloride, also known as N,N,N′,N′-Tetramethylphosphorodiamidic chloride, is a clear colorless to slightly yellow liquid with significant chemical properties. It is a versatile reagent in organic synthesis and has been utilized in the creation of various organic compounds.
Uses
Used in Pharmaceutical Industry:
Bis(dimethylamino)phosphoryl chloride is used as a synthetic reagent for the production of various pharmaceutical compounds. Its application is primarily due to its ability to facilitate the formation of complex organic molecules, which are essential in the development of new drugs and therapies.
Used in Chemical Synthesis:
In the field of chemical synthesis, Bis(dimethylamino)phosphoryl chloride is used as a key intermediate for the synthesis of a wide range of organic compounds. Its utility stems from its ability to participate in various chemical reactions, leading to the formation of diverse products with potential applications in different industries.
Used in Total Synthesis:
Bis(dimethylamino)phosphoryl chloride is used as a crucial component in the total synthesis of complex organic molecules, such as (-)-allohedycaryol and C2-symmetric binaphthyl phosphortriamide. Its role in these syntheses is to provide a stable and reactive platform for the construction of the target molecules.
Used in Research and Development:
In the research and development sector, Bis(dimethylamino)phosphoryl chloride is employed as a valuable tool for exploring new chemical reactions and pathways. Its unique properties make it an attractive candidate for studying the mechanisms of various organic transformations and for developing new synthetic methodologies.
Check Digit Verification of cas no
The CAS Registry Mumber 1605-65-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,6,0 and 5 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1605-65:
(6*1)+(5*6)+(4*0)+(3*5)+(2*6)+(1*5)=68
68 % 10 = 8
So 1605-65-8 is a valid CAS Registry Number.
InChI:InChI=1/C4H12ClN2OP/c1-6(2)9(5,8)7(3)4/h1-4H3
1605-65-8Relevant articles and documents
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Walsh,Toy
, p. 71 (1963)
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Abel,E.W. et al.
, p. 57 - 61 (1965)
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Preparation of organohalosilanes
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, (2008/06/13)
In an industrial process for preparing organohalosilanes by reacting metallic silicon particles with an organohalide in the presence of a copper catalyst, a contact mass composed of the metallic silicon and the catalyst further contains an effective amount of a phosphine chalcogenide compound. The invention drastically increases the silane formation rate and the utilization of silicon without lowering the selectivity of useful silane.
Phosphorylation of cyclic amides
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, (2008/06/13)
Compounds of the general formula STR1 are reacted with a strong base followed by a phosphorylating agent, such as dicyclicaminophosphinic halide or bis-di-lower alkylaminophosphinic halide to produce an imine of the formula STR2 wherein R is dicyclicaminophosphinyloxy or bis-di-lower alkylaminophosphinyloxy. R represents a leaving group which will undergo nucleophilic displacement with nitrogen, oxygen, sulfur and carbon containing nucleophiles, that is, nucleophiles which have, as a reactive site, a nitrogen, oxygen, sulfur or carbon atom, such that, when the cyclic imine undergoes nucleophilic displacement, there is formed C--N, C--O, C--S and C--C bonds between the carbon atom of the cyclic imine and the nucleophilic group. The end products may be utilized as intermediates in the production of pharmaceutically valuable compounds and, in some instances, are pharmaceutically valuable compounds per se.
