16055-80-4 Usage
Description
L-Kynurenine Sulfate is a tryptophan metabolite that serves as a precursor to kynurenic acid and acts as an antagonist of the N-methyl-D-aspartate (NMDA) receptor. It plays a crucial role in various physiological and pathological processes within the body.
Uses
Used in Pharmaceutical Industry:
L-Kynurenine Sulfate is used as an intermediate in the synthesis of various pharmaceutical compounds for its role as a precursor to kynurenic acid. This makes it valuable in the development of treatments for conditions related to the NMDA receptor, such as neurodegenerative diseases and psychiatric disorders.
Used in Research Applications:
L-Kynurenine Sulfate is utilized as a research tool in the study of tryptophan metabolism, kynurenic acid production, and the modulation of NMDA receptor activity. It helps researchers understand the underlying mechanisms of various neurological and psychiatric conditions, as well as the potential therapeutic applications of targeting these pathways.
Used in Neuroprotective Agents:
L-Kynurenine Sulfate is used as a neuroprotective agent due to its antagonistic effect on the NMDA receptor. This property makes it a potential candidate for the development of treatments aimed at reducing neuronal damage and inflammation associated with conditions like Alzheimer's disease, Parkinson's disease, and multiple sclerosis.
Used in Antidepressant and Antianxiety Medications:
Given its role in modulating NMDA receptor activity, L-Kynurenine Sulfate may be used as a component in the development of antidepressant and antianxiety medications. Its ability to influence neurotransmission could contribute to the alleviation of symptoms in individuals suffering from depression and anxiety disorders.
Purification Methods
Crystallise the sulfate from water by addition of EtOH. The (±)-sulfate has m 173o. [Beilstein 14 IV 2562.]
Check Digit Verification of cas no
The CAS Registry Mumber 16055-80-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,0,5 and 5 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 16055-80:
(7*1)+(6*6)+(5*0)+(4*5)+(3*5)+(2*8)+(1*0)=94
94 % 10 = 4
So 16055-80-4 is a valid CAS Registry Number.
InChI:InChI=1/C10H12N2O3.H2O4S/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15;1-5(2,3)4/h1-4,8H,5,11-12H2,(H,14,15);(H2,1,2,3,4)/t8-;/m0./s1
16055-80-4Relevant articles and documents
A concise preparation of the non-proteinogenic amino acid l-kynurenine
Kleijn, Laurens H.J.,Müskens, Frederike M.,Oppedijk, Sabine F.,De Bruin, Gerjan,Martin, Nathaniel I.
supporting information, p. 6430 - 6432 (2013/01/15)
A concise and practical preparation of the non-proteinogenic amino acid l-kynurenine is reported. The synthetic approach is scalable and provides ready access to this valuable amino acid in either l- or d-stereochemistry starting from l- or d-tryptophan, respectively. In the optimized procedure, two discreet oxidation steps are applied sequentially to convert the tryptophan indole ring into the keto-aniline moiety contained within the kynurenine side chain.
