911675-22-4 Usage
Description
(S)-2-(((Benzyloxy)carbonyl)amino)-3-(2-oxoindolin-3-yl)propanoic acid is a chemical compound derived from the amino acid proline, featuring a benzyl ester group and an oxindole group. (S)-2-(((benzyloxy)carbonyl)amino)-3-(2-oxoindolin-3-yl)propanoic acid is recognized for its potential therapeutic applications and its utility as a building block in the synthesis of pharmaceuticals and other organic compounds. Its molecular structure and chemical properties position it as a significant asset in medicinal chemistry research and drug development.
Uses
Used in Pharmaceutical Synthesis:
(S)-2-(((Benzyloxy)carbonyl)amino)-3-(2-oxoindolin-3-yl)propanoic acid is used as a key building block in the pharmaceutical industry for the synthesis of various drugs. Its unique structure allows for the creation of complex molecules with specific biological activities.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, (S)-2-(((benzyloxy)carbonyl)amino)-3-(2-oxoindolin-3-yl)propanoic acid serves as an important compound for studying and understanding the interactions between biological targets and potential therapeutic agents. Its structural features facilitate the design and optimization of new drugs.
Used in Drug Development:
(S)-2-(((Benzyloxy)carbonyl)amino)-3-(2-oxoindolin-3-yl)propanoic acid is utilized in drug development to create novel therapeutics with the aim of modulating biological processes and targeting specific pathways in the body. Its potential applications in this area stem from its ability to interact with various molecular targets, making it a promising candidate for the treatment of various diseases.
Used in Organic Chemistry:
(S)-2-(((benzyloxy)carbonyl)amino)-3-(2-oxoindolin-3-yl)propanoic acid is also used in organic chemistry as a versatile intermediate for the synthesis of a wide range of organic compounds. Its reactivity and functional groups make it a valuable tool for chemists working on the development of new materials and chemical processes.
Check Digit Verification of cas no
The CAS Registry Mumber 911675-22-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,1,6,7 and 5 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 911675-22:
(8*9)+(7*1)+(6*1)+(5*6)+(4*7)+(3*5)+(2*2)+(1*2)=164
164 % 10 = 4
So 911675-22-4 is a valid CAS Registry Number.
911675-22-4Relevant articles and documents
Synthesis and evaluation of oxindoles as promising inhibitors of the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1
Paul, Saurav,Roy, Ashalata,Deka, Suman Jyoti,Panda, Subhankar,Srivastava, Gopal Narayan,Trivedi, Vishal,Manna, Debasis
, p. 1640 - 1654 (2017)
Indoleamine 2,3-dioxygenase 1 (IDO1) is considered as an important therapeutic target for the treatment of cancer, chronic infections and other diseases that are associated with immune suppression. Recent developments in understanding the catalytic mechanism of the IDO1 enzyme revealed that conversion of l-tryptophan (l-Trp) to N-formylkynurenine proceeded through an epoxide intermediate state. Accordingly, we synthesized a series of 3-substituted oxindoles from l-Trp, tryptamine and isatin. Compounds with C3-substituted oxindole moieties showed moderate inhibitory activity against the purified human IDO1 enzyme. Their optimization led to the identification of potent compounds, 6, 22, 23 and 25 (IC50 = 0.19 to 0.62 μM), which are competitive inhibitors of IDO1 with respect to l-Trp. These potent compounds also showed IDO1 inhibition potencies in the low-micromolar range (IC50 = 0.33-0.49 μM) in MDA-MB-231 cells. The cytotoxicity of these potent compounds was trivial in different model cancer (MDA-MB-231, A549 and HeLa) cells and macrophage (J774A.1) cells. Stronger selectivity for the IDO1 enzyme (124 to 210-fold) over the tryptophan 2,3-dioxygenase (TDO) enzyme was also observed for these compounds. These results suggest that the oxindole moiety of the compounds could mimic the epoxide intermediate state of l-Trp. Therefore, the structural simplicity and low-micromolar inhibition potencies of these 3-substituted oxindoles make them quite attractive for further investigation of IDO1 function and immunotherapeutic applications.
