1610031-67-8

Basic information

• Product Name: N-(6-bromopyridin-3-yl)-N-methylacetamide
• CAS NO: 1610031-67-8
• Molecular Weight: 229.076
• Mol File: 1610031-67-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(6-bromopyridin-3-yl)-N-methylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(6-bromopyridin-3-yl)-N-methylacetamide(1610031-67-8)
• EPA Substance Registry System: N-(6-bromopyridin-3-yl)-N-methylacetamide(1610031-67-8)

Safety Data

• Hazardous Substances Data: 1610031-67-8(Hazardous Substances Data)

Upstream product

• 29958-19-8 N-(6-bromo-pyridin-3-yl)-acetamide 
• 74-88-4 methyl iodide 

Relevant articles and documents

Copper-mediated perfluoroalkylation of heteroaryl bromides with (phen)CuRF

The attachment of perfluoroalkyl groups onto organic compounds has been a major synthetic goal over the past several decades. Previously, our group reported phenanthroline-ligated perfluoroalkyl copper reagents, (phen)CuR F, which react with aryl iodides and aryl boronates to form the corresponding benzotrifluorides. Herein the perfluoroalkylation of a series of heteroaryl bromides with (phen)CuCF3 and (phen)CuCF 2CF3 is reported. The mild reaction conditions allow the process to tolerate many common functional groups. Perfluoroethylation with (phen)CuCF2CF3 occurs in somewhat higher yields than trifluoromethylation with (phen)CuCF3, creating a method to generate fluoroalkyl heteroarenes that are less accessible from trifluoroacetic acid derivatives.