16101-70-5Relevant articles and documents
SPIRO COMPOUNDS AS HEPATITIS C VIRUS INHIBITORS
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Paragraph 0544, (2015/11/09)
Disclosed are spiro compounds of formula (I), or stereomers, geometric isomers, tautomers, nitrogen oxides, hydrates, solvates, metabolites, pharmaceutically acceptable salts or prodrugs thereof. The compounds can be used to treat hepatitis C virus (HCV) infection or hepatitis C disease. Furthermore disclosed are pharmaceutical compositions containing the compounds and the method of using the compounds or pharmaceutical compositions in the treatment of HCV infection or hepatitis C disease.
Tetracyano-4,7-indanoquinodimethanes: The first TCNQs with an indan nucleus
Panetta, Charles A.,Sha, Dezhi,Torres, Epifanio,He, Zhuoli,Hussey,Fang, Zheng,Heimer, Norman E.
, p. 1085 - 1090 (2007/10/03)
8,8,9,9-Tetracyano-4,7-indanoquinodimethane 5-chloro-8,8,9,9-tetracyano-4,7-indanoquinodimethane, the first members of the hitherto unreported family of tetracyanoindanoquinodimethanes, have been synthesized from the corresponding 4,7-indandicarboxylic acids by the method of Yamaguchi. The indan-TCNQs are part of a series of polycyclic TCNQs which include 11,11,12,12-tetracyano-9,10-anthraquinodimethane and 9,9,10,10-tetracyano-1,4-naphthoquinodimethane, that have been prepared in our laboratory. A disadvantage found with the earlier polycyclic TCNQs was the non-coplanarity of their rings and the dicyanomethylene moities: a planar system is essential to efficient electrical conductivity of TCNQs in CT salts. X-ray analysis has shown 8,8,9,9-tetracyano-4,7-indanoquinodimethane to be more planar compared with tetracyanoanthraquinodimethanes and tetracyanonaphthoquinodimethanes. The half-wave potentials of the chlorotetracyanoindanoquinodimethane show it to be a stronger electron acceptor than several known TCNQs and its cyclic voltammogram indicate two single-electron reversible redox processes.