1610796-02-5 Usage
Description
Azido-PEG12-NHS ester is a chemical compound that features an azide function on one end of a single molecular weight dPEG12 spacer and a reactive NHS (N-hydroxysuccinimide) ester group on the other end. The dPEG12 spacer is hydrophilic and non-immunogenic, which enhances the water solubility of the target molecule, reduces its immunogenicity, and increases its hydrodynamic volume.
Uses
Used in Bioconjugation:
Azido-PEG12-NHS ester is used as a bioconjugation agent for the covalent attachment of biomolecules, such as proteins, peptides, or other molecules, to various surfaces or other biomolecules. The NHS ester group reacts with primary amines, forming stable amide bonds, while the dPEG12 spacer provides a hydrophilic and non-immunogenic environment that reduces aggregation and non-specific interactions.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Azido-PEG12-NHS ester is used as a component in the development of drug delivery systems. The hydrophilic dPEG12 spacer improves the solubility and bioavailability of drugs, while the NHS ester group allows for the attachment of drug molecules to the delivery system, enhancing their stability and controlled release.
Used in Diagnostics:
Azido-PEG12-NHS ester is also utilized in the development of diagnostic tools, such as imaging agents or biosensors. The azide function can be used for the selective labeling of target molecules, while the dPEG12 spacer provides a hydrophilic environment that reduces background signals and improves the sensitivity of the diagnostic tool.
Used in Material Science:
In the field of material science, Azido-PEG12-NHS ester is used as a building block for the creation of hydrogels, micelles, or other nanostructures with specific properties. The dPEG12 spacer contributes to the hydrophilicity and non-immunogenicity of the resulting materials, while the reactive NHS ester group allows for the incorporation of various functional groups or molecules.
Check Digit Verification of cas no
The CAS Registry Mumber 1610796-02-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,1,0,7,9 and 6 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1610796-02:
(9*1)+(8*6)+(7*1)+(6*0)+(5*7)+(4*9)+(3*6)+(2*0)+(1*2)=155
155 % 10 = 5
So 1610796-02-5 is a valid CAS Registry Number.
1610796-02-5Relevant articles and documents
NOVEL CONNECTED BODY AND USE THEREOF IN SPECIFIC CONJUGATION BETWEEN BIOMOLECULE AND DRUG
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, (2021/05/14)
PROBLEM TO BE SOLVED: To provide: a method for producing a connected body; a method for using the connected body in the production of a uniform conjugate; and a method for applying the conjugate in the treatment of cancer, infectious diseases, and autoimmune diseases. SOLUTION: A novel connected body is provided that includes a 2,3-di-substituted succinic acid group or a 2-mono-substituted or 2,3-di-substituted fumaric acid or maleic acid (trans (E)- or cis (Z)-butenedioic acid) group for conjugating 2 or more compounds/cytotoxic agents per connected body with a cell-binding molecule by specifically bridge-linking to a pair of thiol on the cell-binding molecule. The connected body is exemplified by the following general formula. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT
CONJUGATION LINKERS CONTAINING 2,3-DIAMINOSUCCINYL GROUP
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, (2020/05/19)
Provided is a conjugate of a cytotoxic drug/molecule to a cell-binding molecule with a bis-linker (adual-linker) containing a 2, 3-diaminosuccinyl group. It also relates to preparation of the conjugate of a cytotoxic drug/molecule to a cell-binding molecule with the bis-linker, particularly when the drug having functional groups of amino, hydroxyl, diamino, amino-hydroxyl, dihydroxyl, carboxyl, hydrazine, aldehyde and thiol for conjugation with the bis-linker in a specific manner, as well as the therapeutic use of the conjugates.
CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LIKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS
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, (2018/05/27)
The present invention relates to linkers having a group of propiolyl, substituted acryl (acryloyl), or disubstituted propanoyl, and using such linkers for the conjugation of compounds, in particular, cytotoxic agents to a cell-binding molecule.
