16112-33-7

Basic information

• Product Name: 1,3,4-Thiadiazole, 2,5-bis(4-methylphenyl)-
• Synonyms: 1,3,4-Thiadiazole,2,5-bis(4-methylphenyl);2,5-di-p-tolyl-[1,3,4]thiadiazole;di-p-tolyl-[1,3,4]thiadiazole;Di-p-tolyl-[1,3,4]thiadiazol
• CAS NO: 16112-33-7
• Molecular Formula: C16H14N2S
• Molecular Weight: 266.367
• Mol File: 16112-33-7.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 1,3,4-Thiadiazole, 2,5-bis(4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,4-Thiadiazole, 2,5-bis(4-methylphenyl)-(16112-33-7)
• EPA Substance Registry System: 1,3,4-Thiadiazole, 2,5-bis(4-methylphenyl)-(16112-33-7)

Safety Data

• Hazardous Substances Data: 16112-33-7(Hazardous Substances Data)

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 52693-87-5 4-methylbenzaldehyde hydrazone 
• 5977-87-7 4-methyl-dithiobenzoic acid methyl ester 
• 96907-78-7 4-methyl-N-(2-oxo-2-(4-methylphenyl)ethyl)benzamide 
• 106-38-7 para-bromotoluene 
• 1366397-88-7 2-(p-tolyl)-1,3,4-thiadiazole 
• 3619-22-5 p-toluic hydrazide 
• 60410-77-7 bis(4-methylbenzenethiocarbonyl) sulphide 
• 3335-25-9 4-methylthiobenzoyl chloride 
• 874-60-2 4-methyl-benzoyl chloride 
• 64-17-5 ethanol 
• 120449-42-5 Se-phenyl 4-methylbenzenecarboselenothioate 
• 1530-73-0 4-methyl-N'-(4-methylbenzoyl)benzohydrazide 

Downstream Products

• 24000-81-5 4,4'-(1,3,4-thiadiazole-2,5-diyl)dibenzoic acid 
• 16157-48-5 2,5-bis-(4-trans-styryl-phenyl)-[1,3,4]thiadiazole 
• 16157-50-9 2,5-bis-[4-(trans-2-biphenyl-4-yl-vinyl)-phenyl]-[1,3,4]thiadiazole 

Relevant articles and documents

Structural studies of 2,5-disubstituted 1,3,4-thiadiazole derivatives from dithioesters under the mild condition: Studies on antioxidant, antimicrobial activities, and molecular docking

A series of 2,5-disubstituted 1,3,4-thiadiazole was synthesized and evaluated for their antioxidant and molecular docking studies. These molecules were efficiently synthesized under mild and inexpensive starting material. Construction of these molecules developed using substituted aldehydes and substituted dithioesters in presence of NCS (N-Chorosuccinimide). The compounds 4a, 4b, 4c, 4f, and 4k showed good antibacterial and antioxidant activity among which, 4k possess excellent antibacterial and antioxidant activity. The results of antioxidant activity studies revealed that compound 4k manifested profound antioxidant potential. The molecular docking study was performed with respective newly synthesized compounds to ascertain the binding mode of 4k with respect to the critical proteins involved in biosynthesis and metabolic pathways.

Substituted azole penta-heterocyclic derivatives and solvothermal one-pot synthesis method and application thereof

The invention belongs to the technical field of organic synthesis and particularly discloses a series of substituted azole penta-heterocyclic derivatives and a solvothermal one-pot synthesis method thereof. By the adoption of the solvothermal one-pot synthesis method for preparing the target product, reaction time is short, a solvent is not prone to volatilization in an airtight system, recycling can be realized, production cost is effectively reduced, the advantages of energy conservation and environment friendliness are achieved, operation is easy, yield is high, and the prepared substituted azole penta-heterocyclic derivatives have good anti-microbial biological activity and excellent photophysical properties such as electron conductivity, the fluorescence property and the ultraviolet property, thereby having very high development and application value.

Pd/Cu-catalyzed C-H arylation of 1,3,4-thiadiazoles with (hetero)aryl iodides, bromides, and triflates

The direct C-H arylation of 1,3,4-thiadiazoles with a wide range of (hetero)aryl iodides, bromides, and triflates is described using a Pd/Cu-catalyzed protocol. The methodology is compatible with substrates possessing electron-donating or electron-withdrawing substituents and also tolerates sterically hindered aryl halides. The utility of the developed protocol is demonstrated by a one-pot C-H arylation-Suzuki coupling sequence.