52693-87-5Relevant articles and documents
Ruthenium catalyzed β-selective alkylation of vinylpyridines with aldehydes/ketonesviaN2H4mediated deoxygenative couplings
Lv, Leiyang,Li, Chao-Jun
, p. 2870 - 2875 (2021/03/14)
Umpolung (polarity reversal) tactics of aldehydes/ketones have greatly broadened carbonyl chemistry by enabling transformations with electrophilic reagents and deoxygenative functionalizations. Herein, we report the first ruthenium-catalyzed β-selective alkylation of vinylpyridines with both naturally abundant aromatic and aliphatic aldehyde/ketonesviaN2H4mediated deoxygenative couplings. Compared with one-electron umpolung of carbonyls to alcohols, this two-electron umpolung strategy realized reductive deoxygenation targets, which were not only applicable to the regioselective alkylation of a broad range of 2/4-alkene substituted pyridines, but also amenable to challenging 3-vinyl and steric-embedded internal pyridines as well as their analogous heterocyclic structures.
DNA interaction, anticancer, antibacterial, ROS and lipid peroxidation studies of quinoxaline based organometallic Re(I) carbonyls
Varma, Reena R.,Pandya, Juhee G.,Vaidya, Foram U.,Pathak, Chandramani,Dabhi, Ravi A.,Dhaduk, Milan P.,Bhatt, Bhupesh S.,Patel, Mohan N.
, (2021/05/19)
Hetero mononuclear rhenium(I) complexes (I-V) using ligands (L1-L5) [L1-L5 = 11-((2-chlorobenzylidene)hydrazono)-11H-indeno[1,2-b]quinoxaline (L1), 8-methyl-11-((4-methyl-benzylidene)hydrazono)-11H-indeno[1,2-b]quinoxaline (L2), 11-((4-bromobenzylidene) hydrazono)-8-nitro-11H-indeno[1,2-b]quinoxaline (L3), 11-((4-bromobenzylidene) hydrazono)-8-chloro-11H-indeno[1,2-b]quinoxaline (L4), 8-bromo-11-((4-fluorobenzylidene) hydrazono)-11H-indeno[1,2-b]quinoxaline (L5)] were synthesized and characterized by spectroscopic method. All the synthesized compounds have biological importance. DNA interaction studies gave information about the modes of binding and the nucleolytic efficiency of compounds. The binding of the rhenium complexes to Herring sperm DNA (HS DNA) was monitored by UV–visible spectroscopy, viscosity measurements, and molecular docking studies; groove binding was suggested as the most possible mode. The DNA-complexes binding strength was measured in terms of intrinsic binding constants. In vivo and In vitro cytotoxicity against the eukaryotic and prokaryotic cells gave the toxic nature of the synthesized compounds. An antimicrobial study was carried out by estimating MIC (Minimum Inhibitory Concentration) against two Gram-positive (S. aureus, B. subtilis) and three Gram-negative (S. marcescens, P. aeruginosa, E. coli) bacteria. All synthesized complexes are biologically more active than the corresponding ligands. Complexes were having higher MDA and H2O2 production than ligands.
Submonomer synthesis of peptoids containingtrans-inducingN-imino- andN-alkylamino-glycines
Davern, Carolynn M.,Ison, Elon A.,Lowe, Brandon D.,Proulx, Caroline,Rosfi, Adam
, p. 8401 - 8410 (2021/06/28)
The use of hydrazones as a new type of submonomer in peptoid synthesis is described, giving access to peptoid monomers that are structure-inducing. A wide range of hydrazones were found to readily react with α-bromoamides in routine solid phase peptoid submonomer synthesis. Conditions to promote a one-pot cleavage of the peptoid from the resin and reduction to the correspondingN-alkylamino side chains were also identified, and both theN-imino- andN-alkylamino glycine residues were found to favor thetrans-amide bond geometry by NMR, X-ray crystallography, and computational analyses.
