1611466-05-7Relevant articles and documents
Total Synthesis of (-)-Luminacin D
Malassis, Julien,Bartlett, Nathan,Hands, Kane,Selby, Matthew D.,Linclau, Bruno
, p. 3818 - 3837 (2016/05/24)
A second-generation synthesis of (-)-luminacin D based on an early stage introduction of the trisubstituted epoxide group is reported, allowing access to the natural product in an improved yield and a reduced number of steps (5.4%, 17 steps vs 2.6%, 19 steps). A full account of the optimization work is provided, with the reversal of stereoselection in the formation of the C4 alcohol in equally excellent diastereoselectivity as the key improvement.