161646-29-3

Basic information

• Product Name: Carbamic acid, [(1S)-1-(hydroxymethyl)-2-phenylethyl]-, ethyl ester
• CAS NO: 161646-29-3
• Molecular Formula: C12H17NO3
• Molecular Weight: 223.272
• Mol File: 161646-29-3.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(1S)-1-(hydroxymethyl)-2-phenylethyl]-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1S)-1-(hydroxymethyl)-2-phenylethyl]-, ethyl ester(161646-29-3)
• EPA Substance Registry System: Carbamic acid, [(1S)-1-(hydroxymethyl)-2-phenylethyl]-, ethyl ester(161646-29-3)

Safety Data

• Hazardous Substances Data: 161646-29-3(Hazardous Substances Data)

Upstream product

• 91084-05-8 methyl (S)-2-ethyloxycarbonylamino-3-phenylpropanoate 
• 3182-95-4 L-Phenylalaninol 
• 2244-49-7 O-ethyl S-2-pyridyl carbonothioate 
• 63-91-2 L-phenylalanine 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 190378-48-4 N-ethoxycarbonyl-L-phenylalaninal 
• 541-41-3 chloroformic acid ethyl ester 

Downstream Products

• 188935-00-4 Acetic acid (S)-2-ethoxycarbonylamino-3-phenyl-propyl ester 
• 90719-32-7 (S)-4-Benzyl-2-oxazolidinone 
• 174363-73-6 (S)-2-[2-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-phenylamino]-3-methyl-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester 
• 188935-03-7 (S)-2-[2-((S)-3-Acetoxy-2-ethoxycarbonylamino-propyl)-phenylamino]-3-methyl-butyric acid benzyl ester 
• 188935-04-8 (S)-2-[2-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-phenylamino]-3-methyl-butyric acid 
• 188935-01-5 Acetic acid (S)-3-(2-amino-phenyl)-2-ethoxycarbonylamino-propyl ester 
• 1026740-23-7 (S)-2-[2-((S)-2-Amino-3-hydroxy-propyl)-phenylamino]-3-methyl-butyric acid 

Relevant articles and documents

O-Alkyl S-(Pyridin-2-yl)carbonothiolates: Operationally Simple and Highly Nitrogen-Selective Reagents for Alkoxy Carbonylation of Amino Groups

Amino groups are selectively protected in good yields by reaction with O-Alkyl S-(pyridin-2-yl)carbonothiolates in an appropriate solvent at room temperature in air. Even glucosamine, which contains multiple hydroxyl groups, is selectively N-protected in methanol.

Copper-Catalyzed One-Pot Synthesis of N -Aryl Oxazolidinones from Amino Alcohol Carbamates

An efficient sequential intramolecular cyclization of amino alcohol carbamates followed by Cu-catalyzed cross-coupling with aryl iodides under mild conditions has been developed. The reaction occurred in good yields and tolerated aryl iodides containing functionalities such as nitriles, ketones, ethers, and halogens. Heteroaryl iodides and substituted amino alcohol carbamates were also well tolerated.

Modified Mg: Al hydrotalcite in the synthesis of oxazolidin-2-ones

The modified Mg: Al (3: 1) hydrotalcite has been found to be an efficient catalyst in the conversion of carbamates into oxazolidin-2-ones under mild reaction conditions. A wide variety of oxazolidin-2-ones were obtained with excellent chemical yield. The Royal Society of Chemistry 2005.