1619-73-4

Basic information

• Product Name: 3-Butynoic acid, 2-oxo-4-phenyl-, ethyl ester
• CAS NO: 1619-73-4
• Molecular Formula: C12H10O3
• Molecular Weight: 202.21
• Mol File: 1619-73-4.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: 3-Butynoic acid, 2-oxo-4-phenyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Butynoic acid, 2-oxo-4-phenyl-, ethyl ester(1619-73-4)
• EPA Substance Registry System: 3-Butynoic acid, 2-oxo-4-phenyl-, ethyl ester(1619-73-4)

Safety Data

• Hazardous Substances Data: 1619-73-4(Hazardous Substances Data)

Upstream product

• 4755-77-5 Ethyl oxalyl chloride 
• 536-74-3 phenylacetylene 
• 20207-18-5 rac-2-hydroxy-4-phenyl-3-butynoic acid ethyl ester 
• 6738-06-3 phenylethynylmagnesium bromide 
• 171815-56-8 Ethyl 2-(benzotriazol-1-yl)-2-ethoxy-4-phenyl-3-butynoate 
• 139507-52-1 monoethoxyoxalic acid N-methoxy-N-methylamide 
• 75716-82-4 imidazol-1-yl-oxo-acetic acid ethyl ester 
• 64-17-5 ethanol 
• 2327-22-2 2-oxo-4-phenyl-3-butynoic acid methyl ester 
• 1004-22-4 (phenylethynyl)sodium 

Downstream Products

• 7062-59-1 2-oxo-4-phenyl-3-butynoic acid 
• 1271182-93-4 methyl 2-hydroxy-4-phenylbut-3-ynoate 
• 20207-19-6 propyl 2-hydroxy-4-phenylbut-3-ynoate 
• 1271183-04-0 prop-2-ynyl 2-hydroxy-4-phenylbut-3-ynoate 
• 1271183-01-7 allyl 2-hydroxy-4-phenylbut-3-ynoate 
• 20207-20-9 isopropyl 2-hydroxy-4-phenylbut-3-ynoate 
• 20207-21-0 butyl 2-hydroxy-4-phenylbut-3-ynoate 
• 15432-01-6 4-Phenyl-2-phenylimino-butin-3-saeureaethylester 
• 15432-02-7 4-Phenyl-2-oxo-butin-3-saeureanilid 
• 3551-78-8 N,N'-dibenzylethanediamide 
• 3299-62-5 N,N'-bis(o-tolyl)oxamide 
• 3299-59-0 C₁₉H₁₉NO₃ 
• 3551-75-5 N,N'-bis(3-methylphenyl)oxalamide 
• 620-81-5 N,N'-Diphenyloxamid 

Relevant articles and documents

A simple and efficient method for mild and selective oxidation of propargylic alcohols using TEMPO and calcium hypochlorite

Oxidation of propargylic alcohols to the corresponding aldehydes and ketones was achieved at room temperature using 2,2,6,6-tetramethylpiperidine-1- oxyl (TEMPO) and calcium hypochlorite (Ca(OCl)2). Propargylic diols yielded corresponding dialdehydes as the product. This system was found to be very efficient for both the electron donating and electron withdrawing groups such as methoxy and nitro substituted alcohols, respectively. This method does not require any additives and demonstrates the controlled, selective oxidation of propargylic alcohols affording up to 97% isolated yield. The Royal Society of Chemistry 2013.

Organocatalytic Asymmetric Dearomatization Reaction for the Synthesis of Axial Chiral Allene-Derived Naphthalenones Bearing Quaternary Stereocenters

The highly regio-, diastereo-, and enantioselective dearomatization reaction of 1-substituted 2-naphthols and β,γ-alkynyl-α-imino esters with complete atom economy is disclosed via chiral phosphoric acid catalysis. This protocol provides facile and effici

Activating Pyrimidines by Pre-distortion for the General Synthesis of 7-Aza-indazoles from 2-Hydrazonylpyrimidines via Intramolecular Diels-Alder Reactions

Pyrimidines are almost unreactive partners in Diels-Alder cycloadditions with alkenes and alkynes, and only reactions under drastic conditions have previously been reported. We describe how 2-hydrazonylpyrimidines, easily obtained in two steps from commercially available 2-halopyrimidines, can be exceptionally activated by trifluoroacetylation. This allows a Diels-Alder cycloaddition under very mild reaction conditions, leading to a large diversity of aza-indazoles, a ubiquitous scaffold in medicinal chemistry. This reaction is general and scalable and has an excellent functional group tolerance. A straightforward synthesis of a key intermediate of Bayer's Vericiguat illustrates the potential of this cycloaddition strategy. Quantum mechanical calculations show how the simple N-trifluoroacetylation of 2-hydrazonylpyrimidines distorts the substrate into a transition-state-like geometry that readily undergoes the intramolecular Diels-Alder cycloaddition.