16191-17-6Relevant articles and documents
Creighton,Mitchell
, p. 1304 (1967)
Preparation of dicarboxylate analogues of Cerulenin
Moseley, Jonathan D.,Staunton, James
, p. 819 - 830 (2007/10/03)
We have proposed and synthesized several new structural classes of Cerulenin analogues, which have potential as inhibitors of both fatty acid and polyketide synthase multi-enzyme complexes. These analogues contain cis epoxides bearing flanking carboxylate groups. Our syntheses have been designed to allow access to a wide range of fatty acid and polyketide-like side chains from readily available starting materials in convergent fashion in just four to five steps. In total, ~40 potential analogues have been prepared and characterized, covering all the structural sub-classes proposed, the majority of which constitute novel functional groupings.