783255-70-9Relevant articles and documents
Approaching an experimental electron density model of the biologically active trans-epoxysuccinyl amide group—Substituent effects vs. crystal packing
Shi, Ming W.,Stewart, Scott G.,Sobolev, Alexandre N.,Dittrich, Birger,Schirmeister, Tanja,Luger, Peter,Hesse, Malte,Chen, Yu-Sheng,Spackman, Peter R.,Spackman, Mark A.,Grabowsky, Simon
supporting information, (2017/10/17)
The trans-epoxysuccinyl amide group as a biologically active moiety in cysteine protease inhibitors such as loxistatin acid E64c has been used as a benchmark system for theoretical studies of environmental effects on the electron density of small active i
Preparation of dicarboxylate analogues of Cerulenin
Moseley, Jonathan D.,Staunton, James
, p. 819 - 830 (2007/10/03)
We have proposed and synthesized several new structural classes of Cerulenin analogues, which have potential as inhibitors of both fatty acid and polyketide synthase multi-enzyme complexes. These analogues contain cis epoxides bearing flanking carboxylate groups. Our syntheses have been designed to allow access to a wide range of fatty acid and polyketide-like side chains from readily available starting materials in convergent fashion in just four to five steps. In total, ～40 potential analogues have been prepared and characterized, covering all the structural sub-classes proposed, the majority of which constitute novel functional groupings.
