162052-68-8Relevant articles and documents
Dinucleotides of 4′-C-vinyl- and 5′-C-allylthymidine as substrates for ring-closing metathesis reactions
Kirchhoff, Claus,Nielsen, Poul
, p. 6475 - 6478 (2007/10/03)
Thymidine derivatives containing a 4′-C-vinyl group or a 5′-C-allyl group are synthesized and used as building blocks for three different dinucleotides. These are evaluated as substrates for ring-closing metathesis cyclisations, and a protected 5′-C-allyl
Modified nucleotides
-
, (2008/06/13)
The current invention concerns new modified nucleotides that are accepted by reverse transcriptases and incorporated in to a growing oligonucleotide but are not accepted by polymerases. Oligonucleotides comprising the new modified nucleotides can be cleaved photolytically. Also embraced is a process for the synthesis of the new modified nucleotides, and their use.