1621019-19-9

Basic information

• Product Name: 3-(benzo[d]isoxazol-3-yl)-1-(4-fluorophenyl)pyrrolidine-2,5-dione
• Synonyms: 3-(benzo[d]isoxazol-3-yl)-1-(4-fluorophenyl)pyrrolidine-2,5-dione
• CAS NO: 1621019-19-9
• Molecular Weight: 310.284
• Mol File: 1621019-19-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(benzo[d]isoxazol-3-yl)-1-(4-fluorophenyl)pyrrolidine-2,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(benzo[d]isoxazol-3-yl)-1-(4-fluorophenyl)pyrrolidine-2,5-dione(1621019-19-9)
• EPA Substance Registry System: 3-(benzo[d]isoxazol-3-yl)-1-(4-fluorophenyl)pyrrolidine-2,5-dione(1621019-19-9)

Safety Data

• Hazardous Substances Data: 1621019-19-9(Hazardous Substances Data)

Upstream product

• 1196-29-8 2-hydroxyacetophenoneoxime 
• 1621019-27-9 2-(benzo[d]isoxazol-3-yl)succinic acid 
• 371-40-4 4-fluoroaniline 
• 1621019-26-8 methyl 3-(benzo[d]isoxazol-3-yl)-2,3-dicyanopropanoate 
• 84395-93-7 1,2-benzisoxazole-3-carboxaldehyde 
• 4825-75-6 3-methylbenzo[d]isoxazole 
• 54758-75-7 1-(2-hydroxyphenyl)ethanone O-acetyl oxime 
• 118-93-4 o-hydroxyacetophenone 

Relevant articles and documents

Design and synthesis of new of 3-(benzo[d]isoxazol-3-yl)-1-substituted pyrrolidine-2, 5-dione derivatives as anticonvulsants

A series of 3-(benzo[d]isoxazol-3-yl)-N-substituted pyrrolidine-2, 5-dione (7a-7d, 8a-8d, 9a-9c) have been prepared and evaluated for their anticonvulsant activities. Preliminary anticonvulsant activity was performed using maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) tests after intraperitoneal (ip) injection into mice, which are the most widely employed models for early identification of anticonvulsant candidate. The acute neurological toxicity (NT) was determined applying rotorod test. The quantitative evaluation after oral administration in rats showed that the most active was 3-(benzo[d]isoxazol-3-yl)-1-(4-fluorophenyl) pyrrolidine-2, 5-dione (8a) with ED50 values of 14.90 mg/kg. Similarly the most potent in scPTZ was 3-(benzo[d]isoxazol-3-yl)-1-cyclohexylpyrrolidine-2, 5-dione (7d) with ED50 values of 42.30 mg/kg. These molecules were more potent and less neurotoxic than phenytoin and ethosuximide which were used as reference antiepileptic drugs.