1621686-48-3

Basic information

• Product Name: 3-acetyl-1-benzyl-4-methylindolin-2-one
• CAS NO: 1621686-48-3
• Molecular Weight: 279.338
• Mol File: 1621686-48-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-acetyl-1-benzyl-4-methylindolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-acetyl-1-benzyl-4-methylindolin-2-one(1621686-48-3)
• EPA Substance Registry System: 3-acetyl-1-benzyl-4-methylindolin-2-one(1621686-48-3)

Safety Data

• Hazardous Substances Data: 1621686-48-3(Hazardous Substances Data)

Upstream product

• 5405-17-4 N-benzyl-3-methylaniline 
• 1341155-49-4 C₁₈H₁₇N₃O₂ 

Relevant articles and documents

Aqueous copper nitrate catalyzed synthesis of 3-alkylideneoxindoles from α-diazo-ketoanilides

An economical, practical, and green protocol with which to synthesize 3-alkylideneoxindoles from α-diazo-ketoanilides has been developed. The approach employs inexpensive Cu(NO3)2·3H 2O as catalyst and environmentally friendly water as solvent, and achieves moderate to excellent yields. The method has good tolerance to a range of N-alkyl and N-aryl groups, including electron-withdrawing and electron-donating groups on the aromatic ring, ortho-, meta-, and para-substituents, and -aliphatic and -aromatic keto groups. A plausible mechanism involving intramolecular aromatic metal carbene electrophilic addition as the key step is proposed. Inexpensive Cu(NO3)2· 3H2O catalyst and environmentally friendly water solvent are employed for the transformation of α-diazo-ketoanilides into 3-alkylidene- oxindoles. The process is easily handled, economical, environmentally friendly, and can be used to convert a broad range of substrates in moderate to excellent yields. An intramolecular aromatic metal carbene electrophilic addition mechanism is proposed. Copyright