1623145-56-1

Basic information

• Product Name: (R)-ethyl 2-(3,5-diphenylfuran-2-yl)-3,3,3-trifluoro-2-hydroxypropanoate
• Synonyms: (R)-ethyl 2-(3,5-diphenylfuran-2-yl)-3,3,3-trifluoro-2-hydroxypropanoate
• CAS NO: 1623145-56-1
• Molecular Weight: 390.359
• Mol File: 1623145-56-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-ethyl 2-(3,5-diphenylfuran-2-yl)-3,3,3-trifluoro-2-hydroxypropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-ethyl 2-(3,5-diphenylfuran-2-yl)-3,3,3-trifluoro-2-hydroxypropanoate(1623145-56-1)
• EPA Substance Registry System: (R)-ethyl 2-(3,5-diphenylfuran-2-yl)-3,3,3-trifluoro-2-hydroxypropanoate(1623145-56-1)

Safety Data

• Hazardous Substances Data: 1623145-56-1(Hazardous Substances Data)

Upstream product

• 13081-18-0 ethyl-3,3,3-trifluoropyruvate 
• 102705-79-3 1,2,4-triphenylbut-3-yne-1,2-diol 
• 5369-55-1 2,4-diphenylfuran 

Relevant articles and documents

Catalytic and highly enantioselective Friedel-Crafts type reactions of heteroaromatic compounds with trifluoropyruvate and glyoxylate by a dicationic palladium complex

The highly enantioselective Friedel-Crafts alkylation of furan and thiophene derivatives with trifluoropyruvate, which have never provided the high level of asymmetric induction and yield until now, was achieved by using dicationic palladium complexes as Lewis acid catalysts. Moreover, glyoxylate instead of trifluoropyruvate as an electrophile led to complete change of regioselectivity with 2-trimethylsilylated furan, thiophene, and pyrrole derivatives to give the corresponding heteroarylated products in high yields and enantioselectivities. The respective products with trifluoropyruvate and glyoxylate could also be obtained via sequential catalytic reaction; intramolecular cyclization of alkynyldiols using cationic Au catalyst followed by Friedel-Crafts type reactions using dicationic Pd catalyst.