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16234-15-4

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16234-15-4 Usage

General Description

2-Chloro-4-(morpholin-4-yl)thieno[3,2-d]pyrimidine is a complex organic compound that includes chlorine, nitrogen, and sulfur in a pyrimidine and thieno structure. Its formula is C9H8ClN3OS. As a compound, it is used in various research and development processes, particularly within the pharmaceutical industry. It potentially serves as an intermediate in the synthesis of certain drugs or chemical compounds. It's a relatively specialized chemical and typically requires specific handling and storage conditions due to its reactivity. MIT undergraduates don't generally use this chemical in their standard laboratory procedures.

Check Digit Verification of cas no

The CAS Registry Mumber 16234-15-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,2,3 and 4 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 16234-15:
(7*1)+(6*6)+(5*2)+(4*3)+(3*4)+(2*1)+(1*5)=84
84 % 10 = 4
So 16234-15-4 is a valid CAS Registry Number.
InChI:InChI=1/C10H10ClN3OS/c11-10-12-7-1-6-16-8(7)9(13-10)14-2-4-15-5-3-14/h1,6H,2-5H2

16234-15-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(2-chlorothieno[3,2-d]pyrimidin-4-yl)morpholine

1.2 Other means of identification

Product number -
Other names 2-CHLORO-4-MORPHOLINOTHIENO[3,2-D]PYRIMIDINE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:16234-15-4 SDS

16234-15-4Downstream Products

16234-15-4Relevant articles and documents

PARP-1/PI3K double-target inhibitor or pharmaceutically acceptable salt thereof, preparation method and application thereof

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Paragraph 0157; 0165-0167; 0191; 0198-0200, (2021/07/01)

The invention discloses a PARP-1/PI3K double-target inhibitor or a pharmaceutically acceptable salt thereof, a preparation method and application thereof. According to the invention, the single active component can play a dual inhibition role on PARP-1 and PI3K, so that the dosage is reduced, the treatment effect is improved, and the toxic and side effects are reduced; and the dual inhibition effect on PARP-1 and PI3K is significant, the IC50 value of each target does not exceed 1.0 [mu]M, and the drug using the PARP-1/PI3K double-target inhibitor as the active component can be used for treating a variety of cancers or tumors related to PARP-1 and/or PI3K.

Piperazinone substitute or derivative thereof, preparation method and application thereof, and pharmaceutical composition

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Paragraph 0132; 0143; 0156; 0166; 0169-0172, (2021/06/09)

The invention relates to a piperazinone substitute or a derivative thereof, a preparation method and application thereof, and a pharmaceutical composition, and belongs to the technical field of anti-tumor drugs. The invention designs a piperazinone substituted heterocyclic small molecule compound. The compound shows good affinity to PI3K delta, and the compound can down-regulate the activity of a PI3K pathway in tumor cells, so that the compound shows good inhibitory activity to PI3K delta dependent tumors, and is expected to be used as one of components of a pharmaceutical preparation for treatment of different tumors. The preparation method of the piperazinone substitute is simple and convenient, and the yield is relatively high.

COMBINATION THERAPY WITH A PHOSPHOINOSITIDE 3-KINASE INHIBITOR WITH A ZINC BINDING MOIETY

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Paragraph 0087; 0104, (2020/04/09)

The invention provides a method of treating cancer in a subject in need thereof, comprising administering to the subject: (a) a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein R is hydrogen or an acyl group; and (b) a PD-1 signaling inhibitor; wherein the compound of Formula I or pharmaceutically acceptable salt thereof and the PD-1 signaling inhibitor are administered in amounts which in combination are therapeutically effective. The invention further provides a pharmaceutical composition comprising a compound of Formula I or a pharmaceutically acceptable salt thereof, a PD-1 signaling inhibitor and a pharmaceutically acceptable carrier or excipient.

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