Cas 956390-23-1,2-methyl-5-(4-morpholin-4-yl-thieno[3,2-d]pyrimidin-2-yl)phenylamine

956390-23-1

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Basic information

Product Name: 2-methyl-5-(4-morpholin-4-yl-thieno[3,2-d]pyrimidin-2-yl)phenylamine
Synonyms: 2-methyl-5-(4-morpholin-4-yl-thieno[3,2-d]pyrimidin-2-yl)phenylamine
CAS NO:956390-23-1
Molecular Formula:
Molecular Weight: 326.422
EINECS: N/A
Product Categories: N/A
Mol File: 956390-23-1.mol
Article Data: 1

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: 2-methyl-5-(4-morpholin-4-yl-thieno[3,2-d]pyrimidin-2-yl)phenylamine(CAS DataBase Reference)
NIST Chemistry Reference: 2-methyl-5-(4-morpholin-4-yl-thieno[3,2-d]pyrimidin-2-yl)phenylamine(956390-23-1)
EPA Substance Registry System: 2-methyl-5-(4-morpholin-4-yl-thieno[3,2-d]pyrimidin-2-yl)phenylamine(956390-23-1)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 956390-23-1(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 956390-23-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,5,6,3,9 and 0 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 956390-23:
(8*9)+(7*5)+(6*6)+(5*3)+(4*9)+(3*0)+(2*2)+(1*3)=201
201 % 10 = 1
So 956390-23-1 is a valid CAS Registry Number.

956390-23-1Upstream product

956390-23-1Downstream Products

956390-23-1Relevant articles and documents

The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1- ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer

Folkes, Adrian J.,Ahmadi, Khatereh,Alderton, Wendy K.,Alix, Sonia,Baker, Stewart J.,Box, Gary,Chuckowree, Irina S.,Clarke, Paul A.,Depledge, Paul,Eccles, Suzanne A.,Friedman, Lori S.,Hayes, Angela,Hancox, Timothy C.,Kugendradas, Arumugam,Lensun, Letitia,Moore, Pauline,Olivero, Alan G.,Pang, Jodie,Patel, Sonal,Pergl-Wilson, Giles H.,Raynaud, Florence I.,Robson, Anthony,Saghir, Nahid,Salphati, Laurent,Sohal, Sukhjit,Ultsch, Mark H.,Valenti, Melanie,Wallweber, Heidi J. A.,Nan, Chi Wan,Wiesmann, Christian,Workman, Paul,Zhyvoloup, Alexander,Zvelebil, Marketa J.,Shuttleworth, Stephen J.

supporting information; experimental part, p. 5522 - 5532 (2009/09/06)

Phosphatidylinositol-3-kinase (PI3K) is an important target in cancer due to the deregulation of the PI3K/Akt signaling pathway in a wide variety of tumors. A series of thieno[3,2-d]pyrimidine derivatives were prepared and evaluated as inhibitors of PI3 kinase p110α. The synthesis, biological activity, and further profiling of these compounds are described. This work resulted in the discovery of 17, GDC-0941, which is a potent, selective, orally bioavailable inhibitor of PI3K and is currently being evaluated in human clinical trials for the treatment of cancer.

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