1627211-41-9

Basic information

• Product Name: N,N-dimethyl-5-(4-(morpholinosulfonyl)phenyl)-1H-pyrazole-1-sulfonamide
• Synonyms: N,N-dimethyl-5-(4-(morpholinosulfonyl)phenyl)-1H-pyrazole-1-sulfonamide
• CAS NO: 1627211-41-9
• Molecular Weight: 400.48
• Mol File: 1627211-41-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N,N-dimethyl-5-(4-(morpholinosulfonyl)phenyl)-1H-pyrazole-1-sulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-dimethyl-5-(4-(morpholinosulfonyl)phenyl)-1H-pyrazole-1-sulfonamide(1627211-41-9)
• EPA Substance Registry System: N,N-dimethyl-5-(4-(morpholinosulfonyl)phenyl)-1H-pyrazole-1-sulfonamide(1627211-41-9)

Safety Data

• Hazardous Substances Data: 1627211-41-9(Hazardous Substances Data)

Upstream product

• 98-58-8 4-bromobenzenesulfonyl chloride 
• 834-67-3 4-((4-bromophenyl)sulfonyl)morpholine 
• 133228-21-4 N,N-dimethyl-1H-pyrazole-1-sulfonamide 

Relevant articles and documents

Selective palladium-catalyzed direct C-H arylation of unsubstituted N-protected pyrazoles

A highly selective C-5 arylation of N-dimethylaminosulfamoyl-protected pyrazole with aryl bromides is catalyzed by 2-5 mol% palladium in the presence of triphenylphosphine ligand and carboxylic acid additive. Selectivities up to 45:1 (C-5:C-4) can be achieved by running the reaction in non-polar solvents. A thorough study of scope and limitations shows good general tolerance of aryl bromide substitution. However, limitations on tolerance of ortho-subsitution and protic functional groups were established. Together with a telescoped deprotection step this method presents a viable alternative for the synthesis of C-3 arylated pyrazole building blocks.