834-67-3

Basic information

• Product Name: 4-(4-BROMOBENZENESULFONYL)MORPHOLINE
• Synonyms: 4-(4-BROMOBENZENESULFONYL)MORPHOLINE;4-(4-BROMOPHENYLSULFONYL)MORPHOLINE;4-[(4-BROMOPHENYL)SULPHONYL]MORPHOLINE;4-[(4-Bromophenyl)sulphonyl]morpholine 98%;Morpholine, 4-[(4-bromophenyl)sulfonyl]-;4-[(4-Bromophenyl)sulphonyl]morpholine98%;4-((4-Bromophenyl)
• CAS NO: 834-67-3
• Molecular Formula: C₁₀H₁₂BrNO₃S
• Molecular Weight: 306.18
• Product Categories: blocks;Bromides;Heterocycles;Sulfonamides;Aryl;Organohalides;Sulfonamide;alkyl bromide
• Mol File: 834-67-3.mol
• Article Data: 34

Chemical Properties

• Melting Point: 140-142
• Boiling Point: 415.7 °C at 760 mmHg
• Flash Point: 205.2 °C
• Appearance: /
• Density: 1.594 g/cm³
• Vapor Pressure: 4.03E-07mmHg at 25°C
• Refractive Index: 1.596
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(4-BROMOBENZENESULFONYL)MORPHOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-BROMOBENZENESULFONYL)MORPHOLINE(834-67-3)
• EPA Substance Registry System: 4-(4-BROMOBENZENESULFONYL)MORPHOLINE(834-67-3)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 834-67-3(Hazardous Substances Data)

Usage

General Description

4-(4-Bromobenzenesulfonyl)morpholine is a chemical compound with the molecular formula C10H12BrNO3S. 4-(4-BROMOBENZENESULFONYL)MORPHOLINE is a sulfonamide derivative that contains a morpholine ring with a 4-bromobenzenesulfonyl group attached to it. It is often used in pharmaceutical and chemical research as a building block for the synthesis of other compounds. This chemical is also known to have potential bioactive properties and is used in medicinal chemistry for the development of new drugs. The presence of the bromine and sulfonyl groups makes this compound a versatile reagent for various chemical reactions and applications.

InChI:InChI=1/C10H12BrNO3S/c11-9-1-3-10(4-2-9)16(13,14)12-5-7-15-8-6-12/h1-4H,5-8H2

Upstream product

• 110-91-8 morpholine 
• 98-58-8 4-bromobenzenesulfonyl chloride 
• 20846-02-0 4-bromo-benzenesulfonic acid ethyl ester 
• 34176-08-4 sodium 4-bromobenzenesulfinate 
• 5765-65-1 4-(benzoyloxy)morpholine 
• 2297-64-5 p-bromophenylsulfonyl hydrazide 
• 106-53-6 para-bromobenzenethiol 
• 23328-69-0 4-chloromorpholine 
• 673-40-5 4-bromobenzenediazonium tetrafluoroborate 
• 5467-74-3 4-Bromophenylboronic acid 
• 1828-66-6 morpholine-4-sulfonyl chloride 

Downstream Products

• 486422-68-8 [(4-N-morpholine-4-sulfonyl)phenyl]boronic acid 
• 327106-59-2 [[4-(5-formyl-2-furanyl)phenyl]sulfonyl]-morpholine 
• 1401222-64-7 4-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)sulfonyl)morpholine 
• 957753-66-1 Boc-Trp(4-(morpholinosulfonyl)phenyl)-Gly-OEt 
• 1254319-44-2 (S)-tert-butyl 4-(1-amino-3-(4'-(morpholinosulfonyl)biphenyl-4-yl)-1-oxopropan-2-ylcarbamoyl)tetrahydro-2H-pyran-4-ylcarbamate 
• 1374986-79-4 C₂₃H₂₇NO₇S 
• 1374986-53-4 3-((3-methylbut-2-en-1-yl)oxy)-5-(4-(morpholinosulfonyl)phenoxy)-N-(thiazol-2-yl)benzamide 
• 1374986-54-5 N-(5-fluorothiazol-2-yl)-3-((3-methylbut-2-en-1-yl)oxy)-5-(4-(morpholinosulfonyl)phenoxy)benzamide 
• 1393120-65-4 C₂₂H₂₅NO₇S 
• 486423-23-8 3-amino-6-[4-(morpholin-4-ylsulfonyl)phenyl]-N-(pyridin-3-yl)pyrazine-2-carboxamide 
• 1627211-41-9 N,N-dimethyl-5-(4-(morpholinosulfonyl)phenyl)-1H-pyrazole-1-sulfonamide 

Relevant articles and documents

Synthesis method of sulfonyl secondary amine compound

The invention belongs to the technical field of organic chemistry, and particularly relates to a preparation method of a sulfonyl secondary amine compound. The structure of the compound is characterized by 1H NMR, 13C NMR and HRMS and is confirmed. According to the method, acetonitrile and tetrahydrofuran are used as a mixed solvent, corresponding secondary amine, sulfonyl chloride and boric acid react under the heating condition in the presence of a palladium catalyst, a ligand and alkali, the secondary amine and the sulfonyl chloride firstly generate corresponding amino sulfonyl chloride, and then the amino sulfonyl chloride and the boric acid are subjected to a palladium-catalyzed Suzuki-Miyaura coupling reaction to obtain the target sulfonyl secondary amine compound. The preparation method of the compound has the advantages that corresponding sulfonyl chloride is prevented from being prepared in advance, meanwhile, the conditions are mild, the compatibility of functional groups is high, separation and purification are convenient, and good application value is achieved.

Photochemical C-H Activation Enables Nickel-Catalyzed Olefin Dicarbofunctionalization

Alkenes, ethers, and alcohols account for a significant percentage of bulk reagents available to the chemistry community. The petrochemical, pharmaceutical, and agrochemical industries each consume gigagrams of these materials as fuels and solvents each year. However, the utilization of such materials as building blocks for the construction of complex small molecules is limited by the necessity of prefunctionalization to achieve chemoselective reactivity. Herein, we report the implementation of efficient, sustainable, diaryl ketone hydrogen-atom transfer (HAT) catalysis to activate native C-H bonds for multicomponent dicarbofunctionalization of alkenes. The ability to forge new carbon-carbon bonds between reagents typically viewed as commodity solvents provides a new, more atom-economic outlook for organic synthesis. Through detailed experimental and computational investigation, the critical effect of hydrogen bonding on the reactivity of this transformation was uncovered.

AEROBIC OXIDATIVE SYNTHESIS OF SULFONAMIDE USING Cu CATALYST

The present invention relates to a method for oxidative synthesis of sulfonamides using copper catalysts. , Oxygen (O) is used. 2 The oxidative synthesis of sulfonamides (1) comprises reacting a 2 th or sulfonyl hydrazide primary amine with a sulfonyl hydrazide (sulfonamide) with a copper catalyst on a solvent under the conditions in which the sulphonamide is fed. The oxidation coupling of the present invention showed extensive substrate ranges in an amine comprising a 2 primary amine, 1 primary amine and amine hydrochloride salt. It is worth notable that non-reactive aliphatic sulfonyl hydrazides in previously reported anaerobic systems can be used for the aerobic oxidation coupling of the present invention. The oxidation coupling of the present invention has been more effective on large scale.