1630-62-2

Basic information

• Product Name: (2R)-3-methyl-2-phenyl-1,3-oxazolidine
• CAS NO: 1630-62-2
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.2163
• Mol File: 1630-62-2.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 236.6°C at 760 mmHg
• Flash Point: 68.7°C
• Density: 1.053g/cm³
• Vapor Pressure: 0.0471mmHg at 25°C
• Refractive Index: 1.533
• CAS DataBase Reference: (2R)-3-methyl-2-phenyl-1,3-oxazolidine(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-3-methyl-2-phenyl-1,3-oxazolidine(1630-62-2)
• EPA Substance Registry System: (2R)-3-methyl-2-phenyl-1,3-oxazolidine(1630-62-2)

Safety Data

• Hazardous Substances Data: 1630-62-2(Hazardous Substances Data)

Usage

General Description

(2R)-3-methyl-2-phenyl-1,3-oxazolidine is a chemical compound with the molecular formula C10H13NO. It is a heterocyclic organic compound that belongs to the oxazolidine family. (2R)-3-methyl-2-phenyl-1,3-oxazolidine is a chiral molecule with a stereocenter at the second carbon atom, resulting in two enantiomers, (2R) and (2S). (2R)-3-methyl-2-phenyl-1,3-oxazolidine has been studied for its potential biological activities, including its role as a chiral ligand in asymmetric catalysis and its anti-inflammatory properties. (2R)-3-methyl-2-phenyl-1,3-oxazolidine is important in medicinal chemistry and pharmaceutical research, where its properties and potential applications are being explored.

Upstream product

• 109-83-1 (2-hydroxyethyl)(methyl)amine 
• 100-52-7 benzaldehyde 
• 4222-25-7 3-bromo-3-phenyl-3H-diazirine 
• 100-47-0 benzonitrile 
• 7732-18-5 water 
• 151-50-8 potassium cyanide 
• 64-17-5 ethanol 
• 101-98-4 2-(N-benzyl-N-methyl)amino-1-ethanol 

Downstream Products

• 100617-55-8 2-[methyl-(1-phenyl-but-2-enyl)-amino]-ethanol 
• 57492-53-2 4-methyl-5t-phenyl-(5ar,9ac)-octahydro-pyrano[3,2-f][1,4]oxazepine 
• 57492-53-2 4-methyl-5t-phenyl-(5ar,9at)-octahydro-pyrano[3,2-f][1,4]oxazepine 
• 61710-06-3 7-ethoxy-4-methyl-5-phenyl-[1,4]oxazepane 
• 2300-86-9 2-[(1,3-diphenyl-prop-2-ynyl)-methylamino]-ethanol 
• 101-98-4 2-(N-benzyl-N-methyl)amino-1-ethanol 
• 3790-45-2 1-phenyl-2,3,4,9-tetrahydro-1H-beta-carboline 
• 4164-25-4 1-methyl-2-phenylaziridine 
• 131602-75-0 3-Methyl-2-phenyl-oxazolidine 3-oxide 
• 107-97-1 sarcosine 
• 65-85-0 benzoic acid 
• 288851-67-2 2-N-methyl-N-(1'-phenyl)propylaminoethanol 
• 101286-71-9 2-(N-benzhydryl-N-methylamino)ethyl alcohol 

Relevant articles and documents

Atom-efficient transition-metal-free arylation ofN,O-acetals using diarylzinc reagents through Zn/Zn cooperativity

Exploiting the cooperative action of Lewis acid Zn(C6F5)2with diarylzinc reagents, the efficient arylation ofN,O-acetals to access diarylmethylamines is reported. Reactions take place under mild reaction conditions without the need for transtion-metal catalysis. Mechanistic investigations have revealed that Zn(C6F5)2not only acts as a Lewis acid activator, but also enables the regeneration of nucleophilic ZnAr2species, allowing a limiting 50 mol% to be employed.

Electrooxidative cyclization of hydroxyamino compounds possessing a benzyl group

Several novel 2-aryl-1,3-oxazinane and 2-aryl-1,3-oxazolidine derivatives were synthesized from N-benzyl-2-piperidineethanols and N-benzyl-2- piperidinemethanols, respectively, by using electrooxidative methods in methanol. For these reactions, the yields of the corresponding cyclized compounds were significantly increased by using catalytic amounts of iodide ions. In contrast, 3-dialkylamino-1-phenylpropanols afforded the expected cyclic 6-phenyl-1,3-oxazinane derivatives using only a small excess of base. Georg Thieme Verlag Stuttgart · New York.

Heterogeneous rhodium-catalyzed hydrogenation conditions for the highly effective synthesis of 1,3-oxazolidines from 1,2-amino alcohols and nitriles

A procedure easily to carried out for the synthesis of 1,3-oxazolidines in high yields using 1,2-amino alcohols, nitriles, an atmospheric pressure of hydrogen and catalytic quantities of rhodium on carbon powder is presented. This reaction probably involves the semi-hydrogenation of the nitrile followed by condensation with the amine alcohol. The process may constitute the key step in a two-step sequence for reducing a nitrile into the corresponding aldehyde.