1630042-69-1

Basic information

• Product Name: C₂₈H₂₃ClN₆O₃S
• CAS NO: 1630042-69-1
• Molecular Weight: 559.048
• Mol File: 1630042-69-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₈H₂₃ClN₆O₃S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₈H₂₃ClN₆O₃S(1630042-69-1)
• EPA Substance Registry System: C₂₈H₂₃ClN₆O₃S(1630042-69-1)

Safety Data

• Hazardous Substances Data: 1630042-69-1(Hazardous Substances Data)

Upstream product

• 851545-79-4 3-chloro-4-(thiazol-2-ylmethoxy)aniline 
• 851545-78-3 2-((2-chloro-4-nitrophenoxy)methyl)thiazole 
• 19815-16-8 4-chloro-6-nitro-quinazoline 
• 6943-17-5 6-nitroquinazolin-4-ol 
• 616-79-5 2-amino-5-nitro-benzoic acid 
• 1012041-42-7 4-N-(3-chloro-4-(thiazol-2-ylmethoxy)phenyl)quinazoline-4,6-diamine 
• 133522-40-4 (R)-(-)-1-amino-3-phenyloxy-2-propanol 
• 6160-65-2 1,1'-Thiocarbonyldiimidazole 

Relevant articles and documents

Design, synthesis and bioactivities evaluation of novel quinazoline analogs containing oxazole units

A novel type of quinazoline derivatives, which were designed by the combination of quinazoline as the backbone and oxazole scaffold as the substituent, have been synthesized and their biological activities were evaluated for anti-proliferative activities and EGFR inhibitory potency. Compound 12b demonstrated the most potent inhibitory activity (IC 50=0.95 μmol/L for EGFR), which could be optimized as a potential EGFR inhibitor in the further study. The structures of the synthesized quinazoline analogs and all intermediates were comfirmed by 1H and 13C NMR, 2D NMR spectra, IR spectra and MS spectra. Copyright