133522-40-4

Basic information

• Product Name: (2R)-(+)-1-AMINO-3-PHENOXY-2-PROPANOL
• Synonyms: (2R)-(+)-1-AMINO-3-PHENOXY-2-PROPANOL;(2R)-3-AMINO-1-PHENOXY-2-PROPANOL;2-PROPANOL, 1-AMINO-3-PHENOXY-, (2R)-;(R)-1-AMino-3-phenoxypropan-2-ol
• CAS NO: 133522-40-4
• Molecular Formula: C₉H₁₃NO₂
• Molecular Weight: 167.21
• Mol File: 133522-40-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 330.2±27.0 °C(Predicted)
• Appearance: /
• Density: 1.129±0.06 g/cm3(Predicted)
• PKA: 12.04±0.35(Predicted)
• CAS DataBase Reference: (2R)-(+)-1-AMINO-3-PHENOXY-2-PROPANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-(+)-1-AMINO-3-PHENOXY-2-PROPANOL(133522-40-4)
• EPA Substance Registry System: (2R)-(+)-1-AMINO-3-PHENOXY-2-PROPANOL(133522-40-4)

Safety Data

• Hazardous Substances Data: 133522-40-4(Hazardous Substances Data)

Usage

General Description

"(2R)-(+)-1-AMINO-3-PHENOXY-2-PROPANOL" is a compound with the chemical formula C9H13NO2. It is a chiral compound, meaning it has a non-superimposable mirror image, and the (2R)-(+)- designation indicates its stereochemistry. (2R)-(+)-1-AMINO-3-PHENOXY-2-PROPANOL is commonly used as a chiral auxiliary in asymmetric synthesis, where it helps control the stereochemical outcome of a reaction. It is also used in the production of pharmaceuticals and agrochemicals. Additionally, it has been studied for its potential use in the treatment of conditions such as hypertension and arrhythmias.

Upstream product

• 71031-03-3 (2R)-1,2-epoxy-3-phenoxypropane 
• 140630-37-1 (2R)-1-azido-3-phenoxypropan-2-ol 
• 122-60-1 Phenyl glycidyl ether 
• 4769-73-7 (RS)-1-chloro-3-phenyloxy-2-propanol 
• 140630-39-3 (S)-3-bromo-1-phenoxy-2-propanol 
• 140630-34-8 (S)-1-chloro-2-acetoxy-3-phenoxypropane 
• 140428-47-3 Acetic acid 1-bromomethyl-2-phenoxy-ethyl ester 
• 929548-38-9 (2R,3R,3aS,6R,6aR,3'R,3'aS,6'R,6'aR,5''R)-spiro[6,3',6'-trihydroxy-octahydro[2,3']bi[furo[3,2-b]furan]-3,2''-[5''-phenoxymethyl-1'',3''-oxazolidine]] 
• 86809-23-6 d-1-Phenoxy-2-hydroxy-3-ammoniumpropane-D-pantoate 
• 86809-23-6 l-1-Phenoxy-2-hydroxy-3-ammoniumpropane-L-pantoate 

Downstream Products

• 1630042-69-1 C₂₈H₂₃ClN₆O₃S 

Relevant articles and documents

Synthesis and structure-activity relationship of a novel class of 15-membered macrolide antibiotics known as '11a-azalides'

Macrolide antibiotics are widely prescribed for the treatment of respiratory tract infections; however, the increasing prevalence of macrolide-resistant pathogens is a public health concern. Therefore, the development of new macrolide scaffolds with activities against resistant pathogens is urgently needed. An efficient method for reconstructing the erythromycin A macrolactone skeleton has been established. Based on this methodology, novel 15-membered macrolides, known as '11a-azalides', with substituents at the C12, C13, or C4″ positions were synthesized and their antibacterial activities were evaluated. These derivatives showed promising antibacterial activities against erythromycin-resistant Streptococcus pneumoniae. Among them, the C4″ substituted derivatives had the most potent activity against erythromycin-resistant S. pneumoniae.

Resolution of β-aminoalcohols and 1,2-diamines using fractional crystallization of diastereomeric salts of dehydroabietic acid

(S)-(+)-1-Amino-3-phenyloxy-2-propanol, (R)-(-)-2-amino-1-phenylethanol, (S)-(+)-1-amino-2-propanol, (1S,2S)-(+)-2-aminocyclohexanol and (1S,2S)-(+)-1,2-diaminocyclohexane were resolved using dehydroabietic acid. It was shown that good to high enantiomeric purity, between 81～>99% ee, was obtained and that dehydroabietic acid could be easily and efficiently recovered in a reusable form.

RESOLUTION OF dl-1-PHENOXY-2-HYDROXY-3-AMINOPROPANE INTO ENANTIOMERS

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