163217-67-2 Usage
Description
2-[2-(4-Fluorophenyl)-2-oxo-1-phenyl-ethyl]-4-methyl-3-oxo-pentanoic Acid, (4-Benzyloxy-phenyl)-amide is a complex organic compound with a unique chemical structure. It is an intermediate of the metabolite of Atorvastin, a drug used for treating hypercholesterolemia. 2-[2-(4-Fluorophenyl)-2-oxo-1-phenyl-ethyl]-4-methyl-3-oxo-pentanoic Acid, (4-Benzyloxy-phenyl)-amide is characterized by its off-white solid appearance and plays a significant role in the pharmaceutical industry due to its association with Atorvastin.
Uses
Used in Pharmaceutical Industry:
2-[2-(4-Fluorophenyl)-2-oxo-1-phenyl-ethyl]-4-methyl-3-oxo-pentanoic Acid, (4-Benzyloxy-phenyl)-amide is used as an intermediate in the synthesis of Atorvastin for the treatment of hypercholesterolemia. Atorvastin is a selective, competitive HMG-CoA reductase inhibitor, specifically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.
Used in Cardiovascular Applications:
In the field of cardiovascular health, 2-[2-(4-Fluorophenyl)-2-oxo-1-phenyl-ethyl]-4-methyl-3-oxo-pentanoic Acid, (4-Benzyloxy-phenyl)-amide contributes to the development of Atorvastin, which is essential in managing and reducing the risk of cardiovascular diseases associated with high cholesterol levels. By lowering LDL-cholesterol and triglycerides, Atorvastin helps in preventing the formation of plaques in the arteries, thus reducing the risk of heart attacks and strokes.
Used in Research and Development:
2-[2-(4-Fluorophenyl)-2-oxo-1-phenyl-ethyl]-4-methyl-3-oxo-pentanoic Acid, (4-Benzyloxy-phenyl)-amide is also utilized in research and development for the study of HMG-CoA reductase inhibitors and their potential applications in treating other related conditions. The understanding of its chemical properties and interactions with other molecules can lead to the discovery of new drugs and therapies for various health issues.
Check Digit Verification of cas no
The CAS Registry Mumber 163217-67-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,3,2,1 and 7 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 163217-67:
(8*1)+(7*6)+(6*3)+(5*2)+(4*1)+(3*7)+(2*6)+(1*7)=122
122 % 10 = 2
So 163217-67-2 is a valid CAS Registry Number.
163217-67-2Relevant articles and documents
Atorvastatin Derived HMG-CoA Reductase Degradation Inducing Compound
-
, (2020/12/01)
The present invention relates to a HMG-CoA reductase degradation-inducing compound and, more specifically, to a bifunctional compound in which atorvastatin and E3 ubiquitin ligase binding moiety are chemically linked as HMG-CoA reductase binding moiety, to a production method thereof, to a HMG-CoA reductase degradation method using the same, and to a pharmaceutical composition for preventing or treating HMG-CoA reductase-related diseases, comprising the same.
Synthesis of deuterium-labeled atorvastatin and its metabolites for use as internal standards in a LC/MS/MS method developed for quantitation of the drug and its metabolites in human serum
Chen, Bang-Chi,Sundeen, Joseph E.,Guo, Peng,Bednarz, Mark S.,Hangeland, Jon J.,Ahmed, Syed Z.,Jemal, Mohammed
, p. 261 - 270 (2007/10/03)
D5-labeled isotopomers of atorvastatin, atorvastatin lactone and its hydroxy metabolites were synthesized as internal standards for use in a LC/MS/MS method developed for the simultaneous quantitative determination of atorvastatin and its hydroxy metabolites in human serum. d5-Atorvastatin and d5-atorvastatin lactone were prepared from d5-aniline whereas their corresponding hydroxy metabolites were synthesized using d5-benzaldehyde.
