16339-07-4

Basic information

• Product Name: 1-methyl-4-nitrosopiperazine
• Synonyms: 1-methyl-4-nitrosopiperazine;N-nitroso-N'-methylpiperazine;NITROSO-N-METHYLPIPERAZINE;1-NITROSO-4-METHYLPIPERAZINE;NITROSOMETHYLPIPERAZINE;N-METHYLNITROSOPIPERAZINE;N-NITROSOMETHYLPIPERAZINE;n-methyl-npz
• CAS NO: 16339-07-4
• Molecular Formula: C₅H₁₁N₃O
• Molecular Weight: 129.16034
• EINECS: 240-409-3
• Mol File: 16339-07-4.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 239.23°C (rough estimate)
• Flash Point: 97.1°C
• Appearance: /
• Density: 1.1508 (rough estimate)
• Vapor Pressure: 0.0463mmHg at 25°C
• Refractive Index: 1.5070 (estimate)
• PKA: 6.50±0.42(Predicted)
• CAS DataBase Reference: 1-methyl-4-nitrosopiperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-4-nitrosopiperazine(16339-07-4)
• EPA Substance Registry System: 1-methyl-4-nitrosopiperazine(16339-07-4)

Safety Data

• Hazardous Substances Data: 16339-07-4(Hazardous Substances Data)

Usage

Safety Profile

Poison by ingestion. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. Many N-nitroso compounds are carcinogens. When heated to decomposition it emits toxic fumes of NOx. See also NNITROSO COMPOUNDS.

InChI:InChI=1/C5H11N3O/c1-7-2-4-8(6-9)5-3-7/h2-5H2,1H3

Upstream product

• 109-01-3 1-methyl-piperazine 
• 543-67-9 n-propyl nitrite 
• 544-16-1 n-Butyl nitrite 
• 70434-12-7 2-hydroxyethyl nitrite 

Downstream Products

• 6928-85-4 N-amino-N'-methylpiperazine 
• 109-01-3 1-methyl-piperazine 
• 140-79-4 N,N'-dinitrosopiperazine 
• 116876-95-0 1-Amino-1,4-dibenzyl-4-methylpiperazinium Dichloride 
• 116876-93-8 1-(3,4-Dimethoxybenzylideneamino)-4-methylpiperazine 
• 343864-02-8 1-methyl[3,3,5,5-D₄]piperazine 

Relevant articles and documents

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Electrochemical Nonacidic N-Nitrosation/N-Nitration of Secondary Amines through a Biradical Coupling Reaction

An acid-free N-nitrosation/nitration of the N?H bonds in secondary amines with Fe(NO3)3 ? 9H2O as the nitroso/nitro source through an electrocatalyzed radical coupling reaction was developed. Cyclic aliphatic amines and N-heteroaromatic compounds were N-nitrosated and N-nitrated, respectively, under mild conditions. Control and competition experiments, as well as kinetic studies, demonstrate that N-nitrosation and N-nitration involve two different radical reaction pathways involving N+ and N. radicals. Moreover, the electrocatalysis method enables the preferential activation of the N?H bond over the electrode and thus provides high selectivity for specific N atoms. Finally, this strategy exhibits a broad scope and provides a green and straightforward approach to generate useful N-nitroso/nitro compounds in good yields. (Figure presented.).

Oxazolidinone compound containing combined aromatic hydrazine and its preparation method

The invention relates to oxazolidinone compound containing combined aromatic hydrazine shown in general formula I, its optical isomer, pharmaceutical acceptable salt and/or solvent compound, and it preparation method, and the drug composition containing the compound, wherein the substituent groups R1, R2, R3, X and A rings have the meaning given in the specification. The invention further relatesto the compound, the substituent group, solvent compound or application of its prodrug using as antibacterial drug in treatment, and application of treating gram positive bacterial infection and mycobacterium tuberculosis infection especially.