163457-23-6 Usage
Description
3,3-Difluoropyrrolidine hydrochloride is a beige solid that serves as a versatile building block in the synthesis of various compounds with potential applications in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
3,3-Difluoropyrrolidine hydrochloride is used as a building block for the synthesis of:
Triazole substituted prolyl difluoropyrrolidines, which are potential inhibitors of dipeptidyl peptidase-4 (DPP-4). These inhibitors can be utilized in the development of treatments for type 2 diabetes and other related conditions.
Dual leucine zipper kinase (DLK) inhibitors, which may have potential applications in the treatment of neurodegenerative diseases and other conditions associated with the dysregulation of DLK.
Additionally, 3,3-Difluoropyrrolidine hydrochloride is used as a reactant in the preparation of cyclic and acyclic β-aminofluoroalkenes via allylic amination using the Pd catalyst. This process can lead to the development of novel compounds with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 163457-23-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,3,4,5 and 7 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 163457-23:
(8*1)+(7*6)+(6*3)+(5*4)+(4*5)+(3*7)+(2*2)+(1*3)=136
136 % 10 = 6
So 163457-23-6 is a valid CAS Registry Number.
InChI:InChI=1/C4H7F2N.ClH/c5-4(6)1-2-7-3-4;/h7H,1-3H2;1H
163457-23-6Relevant articles and documents
COMPOUNDS AND COMPOSITIONS AS MODULATORS OF TLR SIGNALING
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Paragraph 0436, (2020/10/20)
The present disclosure relates to compounds, pharmaceutical compositions comprising such compounds, and use of such compounds in methods of treatment or in medicaments for treatment of inflammatory diseases and certain neurological disorders that are related to inflammatory signaling processes, including but not limited to misfolded proteins.
NOVEL BETULINIC SUBSTITUTED AMIDE DERIVATIVES AS HIV INHIBITORS
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Page/Page column 57, (2017/02/24)
The present invention relates to novel betulinic substituted amide compounds of formula (I); and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, X, Y, Z1, Z2, Z3 and are Formula (II) as defined herein. The invention novel betulinic substituted amide derivatives, related compounds, and pharmaceutical compositions useful for the therapeutic treatment of viral diseases and particularly HIV mediated diseases.
PYRAZOLE DERIVATIVE
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Page/Page column 62, (2010/11/27)
A compound represented by Formula (I): wherein Ar1 represents Formula (II): Ar2 represents a 5- or 6-membered aromatic heterocyclic group which may be substituted; and X represents Formula (III): a salt thereof, or a solvate of the compound or the salt. A potent platelet aggregation suppressant which does not inhibit COX-1 and COX-2 is provided.
