1638291-19-6

Basic information

• Product Name: 5-bromo-2-methoxy-N-methyl-N-(4-methylbenzenesulfonyl)benzenecarboxamide
• Synonyms: 5-bromo-2-methoxy-N-methyl-N-(4-methylbenzenesulfonyl)benzenecarboxamide
• CAS NO: 1638291-19-6
• Molecular Weight: 398.277
• Mol File: 1638291-19-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-bromo-2-methoxy-N-methyl-N-(4-methylbenzenesulfonyl)benzenecarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-2-methoxy-N-methyl-N-(4-methylbenzenesulfonyl)benzenecarboxamide(1638291-19-6)
• EPA Substance Registry System: 5-bromo-2-methoxy-N-methyl-N-(4-methylbenzenesulfonyl)benzenecarboxamide(1638291-19-6)

Safety Data

• Hazardous Substances Data: 1638291-19-6(Hazardous Substances Data)

Upstream product

• 630050-32-7 3-bromo-N-(4-methylbenzenesulfonyl)benzenecarboxamide 
• 1638287-10-1 5-bromo-2-methoxy-N-(4-methylbenzenesulfonyl)benzenecarboxamide 
• 74-88-4 methyl iodide 
• 1711-09-7 3-bromobenzoyl chloride 
• 70-55-3 toluene-4-sulfonamide 

Downstream Products

• 7120-41-4 methyl 5-bromo-2-methoxybenzoate 
• 2476-35-9 5-bromo-2-methoxybenzoic acid 
• 80866-82-6 5-bromo-2-methoxy-benzyl alcohol 
• 338385-91-4 2-(5-bromo-2-methoxyphenyl)propan-2-ol 
• 1638287-22-5 1-(5-bromo-2-methoxyphenyl)-2-(triphenylphosphanylidene)ethanone 

Relevant articles and documents

Room-temperature ortho-alkoxylation and -halogenation of N-tosylbenzamides by using palladium(II)-catalyzed C-H activation

The N-tosylcarboxamide group can direct the room-temperature palladium-catalyzed C-H alkoxylation and halogenation of substituted arenes in a simple and mild procedure. The room-temperature stoichiometric cyclopalladation of N-tosylbenzamide was first studied, and the ability of the palladacycle to react with oxidants to form C-X and C-O bonds under mild conditions was demonstrated. The reaction conditions were then adapted to promote room-temperature ortho-alkoxylations and ortho-halogenations of N-tosylbenzamides using palladium as catalyst. The scope and limitation of both alkoxylations and halogenations was studied and the subsequent functional transformation of the N-tosylcarboxamide group through nucleophilic additions was evaluated. This methodology offers a simple and mild route to diversely functionalized arenes.