1639-60-7

Basic information

• Product Name: PROPOXYPHENE HYDROCHLORIDE
• Synonyms: DARVON;DEXTROPROPOXYPHENE HYDROCHLORIDE;PROPOXYPHENE HYDROCHLORIDE;(+)-1,2-diphenyl-2-propionoxy-3-methyl-4-dimethylaminobutanehydrochloride;(+)-hlorid;algaphan;(αS)-α-[(1R)-2-(DiMethylaMino)-1-Methylethyl]-α-phenylbenzeneethanol Propanoate Hydrochloride;D-Propoxyphene-d5 HCl
• CAS NO: 1639-60-7
• Molecular Formula: C₂₂H₂₉NO₂*ClH
• Molecular Weight: 375.93
• EINECS: 216-683-5
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Amines;Aromatics
• Mol File: 1639-60-7.mol
• Article Data: 0

Chemical Properties

• Melting Point: 165-1670C
• Boiling Point: 444 °C at 760 mmHg
• Flash Point: 11 °C
• Appearance: White solid
• Storage Temp.: -20°C Freezer
• Solubility: Very soluble in water, freely soluble in ethanol (96 per cent).
• Water Solubility: 3.7mg/L(25 oC)
• Stability: No data available.
• CAS DataBase Reference: PROPOXYPHENE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: PROPOXYPHENE HYDROCHLORIDE(1639-60-7)
• EPA Substance Registry System: PROPOXYPHENE HYDROCHLORIDE(1639-60-7)

Safety Data

• Hazard Codes: F,T
• Statements: 11-23/24/25-39/23/24/25
• Safety Statements: 16-36/37-45
• RIDADR: 3249
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 1639-60-7(Hazardous Substances Data)

Usage

Description

PROPOXYPHENE HYDROCHLORIDE, also known as Dextropropoxyphene, is a controlled substance belonging to the opiate class. It is a potent analgesic with narcotic properties, where the α-dl-and d-diastereoisomers exhibit significant analgesic activity, while the β-diastereoisomers are substantially inactive. It is a white solid and is commonly known by its brand names Darvon (Xanodyne) and Dolene (Clonmel).

Uses

Used in Pharmaceutical Industry:
PROPOXYPHENE HYDROCHLORIDE is used as an analgesic for the management of moderate to severe pain. Its potent analgesic properties make it effective in providing relief from various types of pain, including postoperative, post-traumatic, and dental pain.
Used in Narcotic Pain Management:
PROPOXYPHENE HYDROCHLORIDE is used as a narcotic analgesic for the treatment of severe pain that may not be adequately managed with non-narcotic medications. Its strong pain-relieving effects make it a valuable option in the management of severe pain conditions.
Used in Controlled Substance Regulation:
As a controlled substance, PROPOXYPHENE HYDROCHLORIDE is used in the regulation and monitoring of its distribution, prescription, and use. This is to prevent misuse, abuse, and diversion of the drug, ensuring that it is used responsibly and only for legitimate medical purposes.

Safety Profile

A human poison by ingestion. An experimental poison by ingestion, intraperitoneal, subcutaneous, intravenous, and intramuscular routes. Human systemic effects by ingestion: anorexia, ataxia, chronic pulmonary edema, cyanosis, increased body temperature, jaundice, nausea or vomiting, sleep disturbance. Experimental teratogenic and reproductive effects. When heated to decomposition it emits very toxic fumes of HCl and NOx. See also PROPOXYPHENE.

InChI:InChI=1/C22H29NO2.2ClH/c1-5-21(24)25-22(18(2)17-23(3)4,20-14-10-7-11-15-20)16-19-12-8-6-9-13-19;;/h6-15,18H,5,16-17H2,1-4H3;2*1H/t18-,22+;;/m1../s1

Downstream Products

• 24274-73-5 (E)-1,2-diphenyl-2-butene 
• 35947-82-1 Z-1,2-diphenyl-2-butene 
• 76290-86-3 cis-4-Dimethylamino-3-methyl-1,2-diphenyl-buten-⁽¹⁾ 
• 19928-09-7 trans-4-Dimethylamino-3-methyl-1,2-diphenyl-buten-⁽¹⁾ 

Related news

Semiautomated Assay for the Simultaneous Determination of PROPOXYPHENE HYDROCHLORIDE (cas 1639-60-7) and Paramethasone Acetate in Coated Single Tablets08/02/2019

A semiautomated method for the simultaneous determination of propoxyphene hydrochloride and paramethasone acetate is described for coated tablets. A novel device for the removal and dissolution of tablet coatings is outlined. Solutions are sampled with an automatic sampler at the rate of 20/hr. ...detailed

Mathematical Model for In Vitro Drug Release from Controlled Release Dosage Forms Applied to PROPOXYPHENE HYDROCHLORIDE (cas 1639-60-7) Pellets08/01/2019

The in vitro release of drugs from controlled-release dosage forms has been studied in terms of a diffusion model. The model has been applied to a pellet formulation containing propoxyphene hydrochloride. It is demonstrated that the model may be used to predict the drug release profile adequatel...detailed

High-pressure liquid chromatographic determination of PROPOXYPHENE HYDROCHLORIDE (cas 1639-60-7) in tablets and capsules07/29/2019

The determination of propoxyphene hydrochloride by gas chromatography (GC) has been examined. Under a number of operating conditions significant on-column decomposition has occurred. The amounts of decomposition have been found to be dependent on sample size, flow-rate, column temperature, liqui...detailed

Neonatal withdrawal symptoms associated with maternal use of PROPOXYPHENE HYDROCHLORIDE (cas 1639-60-7) (Darvon)07/28/2019

Withdrawal symptoms in a neonate whose mother had been a chronic user of propoxyphene hydrochloride have not, as far as we are aware, been reported. We observed withdrawal symptoms in a neonate at 20 hours of age; the mother had taken propoxyphene hydrochloride regularly for over 3 years prior t...detailed

Left bundle branch block associated with PROPOXYPHENE HYDROCHLORIDE (cas 1639-60-7) poisoning07/26/2019

Described is the case of a patient who developed left bundle branch block following acute propoxyphene hydrochloride overdosage. The left bundle branch block was transient and associated with no permanent sequelae. Previously documented cardiac abnormalities, specific narcotic antagonist therapy...detailed